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High serum alanine aminotransferase is associated with the risk of colorectal adenoma in Korean men

Title
High serum alanine aminotransferase is associated with the risk of colorectal adenoma in Korean men
Authors
Moon C.M.Yun K.E.Ryu S.Chang Y.Park D.I.
Ewha Authors
문창모
SCOPUS Author ID
문창모scopus
Issue Date
2017
Journal Title
Journal of Gastroenterology and Hepatology (Australia)
ISSN
0815-9319JCR Link
Citation
vol. 32, no. 7, pp. 1310 - 1317
Keywords
alanine aminotransferasecolorectal adenomametabolic syndromenon-alcoholic fatty liver disease
Publisher
Blackwell Publishing
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Background and Aim: An elevated alanine aminotransferase (ALT) is frequently observed in subjects with metabolic syndrome, which is associated with the risk of colorectal adenoma (CRA). However, the relationship between ALT and CRA remains unclear. Therefore, we aimed to investigate whether high serum ALT is associated with the risk of CRA in a metabolically healthy population. Methods: We conducted this cross-sectional study in 27,717 asymptomatic Korean adults who underwent a health checkup. Subjects were categorized as adenoma-free, hyperplastic polyp, low-risk adenoma, or high-risk adenoma. High-risk adenoma was defined as three or more adenomas, any adenoma ≥ 10 mm, or adenoma with high-grade dysplasia or villous features. Results: Among all participants, 10.3% and 1.5% of cases were categorized as low-risk and high-risk adenoma, respectively. In multivariate analyses adjusting for age, sex, body mass index, smoking habits, alcohol intake, regular exercise, aspirin and analgesics use, family history of colon cancer, education level, fatty liver, high-sensitivity C reactive protein, homeostasis model assessment of insulin resistance, total cholesterol, and triglyceride, an increase in ALT was positively associated with the prevalence of low-risk and high-risk adenoma (P for trend = 0.029 and 0.027, respectively). The highest quartile group of ALT level showed a significantly increased prevalence in low-risk (odds ratio, 1.17) and high-risk adenoma (odds ratio, 1.48) groups compared with the lowest quartile group. This phenomenon persisted in the subgroup analysis in men, but not in women. Conclusions: In the asymptomatic healthy population, high serum ALT is significantly associated with the risk of CRA. © 2016 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd
DOI
10.1111/jgh.13684
Appears in Collections:
의과대학 > 의학과 > Journal papers
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