Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 정송미 | * |
dc.date.accessioned | 2017-08-25T05:08:07Z | - |
dc.date.available | 2017-08-25T05:08:07Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 1879-355X | * |
dc.identifier.other | OAK-20859 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/235694 | - |
dc.description.abstract | PURPOSE: To elucidate the proper length and prognostic value of resection margins in rectal cancer patients who received preoperative chemoradiotherapy (CRT) followed by curative total mesorectal excision (TME).METHODS AND MATERIALS: A total of 1476 rectal cancer patients staging cT3-4N0-2M0 were analyzed. All patients received radiation dose of 50.4 Gy in 28 fractions with concurrent 5-fluorouracil or capecitabine. Total mesorectal excision was performed 4 to 8 weeks after radiation therapy.RESULTS: The recurrence-free survival (RFS) at 5 years showed a significant difference between 3 groups: patients with circumferential resection margin (CRM) ≤1 mm, CRM 1.1 to 5 mm, and CRM >5 mm (46.2% vs 68.6% vs 77.5%, P<.001). Patients with CRM ≤1 mm showed a significantly higher cumulative incidence of locoregional recurrence (P<.001) and distant metastasis (P<.001) at 5 years compared with the other 2 groups. Patients with CRM 1.1 to 5 mm showed a significantly higher cumulative incidence of distant metastasis (P<.001), but not locoregional recurrence (P=.192), compared with those with CRM >5 mm. Distal resection margin (≤5 vs >5 mm) did not show any significant difference in cumulative incidence of locoregional recurrence (P=.310) and distant metastasis (P=.926).CONCLUSION: Rectal cancer patients with CRM ≤1 mm are a high-risk group, with the lowest RFS. Patients with CRM 1.1 to 5 mm may be at intermediate risk, with moderately increased distant recurrence. Distal resection margin was not significantly associated with RFS in rectal cancer after neoadjuvant CRT and total mesorectal excision. Copyright © 2017 Elsevier Inc. All rights reserved. | * |
dc.language | English | * |
dc.title | Continuous Effect of Radial Resection Margin on Recurrence and Survival in Rectal Cancer Patients Who Receive Preoperative Chemoradiation and Curative Surgery: A Multicenter Retrospective Analysis | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 98 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 647 | * |
dc.relation.lastpage | 653 | * |
dc.relation.journaltitle | International journal of radiation oncology, biology, physics | * |
dc.identifier.doi | 10.1016/j.ijrobp.2017.03.008 | * |
dc.identifier.wosid | WOS:000403084700029 | * |
dc.identifier.scopusid | 2-s2.0-85026287609 | * |
dc.author.google | Sung S. | * |
dc.author.google | Kim S.H. | * |
dc.author.google | Lee J.H. | * |
dc.author.google | Nam T.K. | * |
dc.author.google | Jeong S. | * |
dc.author.google | Jang H.S. | * |
dc.author.google | Song J.H. | * |
dc.author.google | Lee J.W. | * |
dc.author.google | Bae J.M. | * |
dc.contributor.scopusid | 정송미(55756694500) | * |
dc.date.modifydate | 20240318140240 | * |