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Brain changes in overweight/obese and normal-weight adults with type 2 diabetes mellitus

Title
Brain changes in overweight/obese and normal-weight adults with type 2 diabetes mellitus
Authors
Yoon S.Cho H.Kim J.Lee D.-W.Kim G.H.Hong Y.S.Moon S.Park S.Lee S.Bae S.Simonson D.C.Lyoo I.K.
Ewha Authors
홍영선류인균윤수정김정윤
SCOPUS Author ID
홍영선scopus; 류인균scopus; 윤수정scopus; 김정윤scopus
Issue Date
2017
Journal Title
Diabetologia
ISSN
0012-186XJCR Link
Citation
vol. 60, no. 7, pp. 1207 - 1217
Keywords
Cognitive functionGrey matterObesityOverweightType 2 diabetes mellitusWhite matter
Publisher
Springer Verlag
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Aims/hypothesis: Overweight and obesity may significantly worsen glycaemic and metabolic control in type 2 diabetes. However, little is known about the effects of overweight and obesity on the brains of people with type 2 diabetes. Here, we investigate whether the presence of overweight or obesity influences the brain and cognitive functions during early stage type 2 diabetes. Methods: This study attempted to uncouple the effects of overweight/obesity from those of type 2 diabetes on brain structures and cognition. Overweight/obese participants with type 2 diabetes had more severe and progressive abnormalities in their brain structures and cognition during early stage type 2 diabetes compared with participants with normal weight. Relationships between each of these measures and disease duration were also examined. Results: Global mean cortical thickness was lower in the overweight/obese type 2 diabetes group than in the normal-weight type 2 diabetes group (z = −2.96, p for group effect = 0.003). A negative correlation was observed between disease duration and global mean white matter integrity (z = 2.42, p for interaction = 0.02) in the overweight/obese type 2 diabetes group, but not in the normal-weight type 2 diabetes group. Overweight/obese individuals with type 2 diabetes showed a decrease in psychomotor speed performance related to disease duration (z = −2.12, p for interaction = 0.03), while normal-weight participants did not. Conclusions/interpretation: The current study attempted to uncouple the effects of overweight/obesity from those of type 2 diabetes on brain structures and cognition. Overweight/obese participants with type 2 diabetes had more severe and progressive abnormalities in brain structures and cognition during early stage type 2 diabetes compared with normal-weight participants. © 2017, Springer-Verlag Berlin Heidelberg.
DOI
10.1007/s00125-017-4266-7
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의과대학 > 의학과 > Journal papers
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