Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권오란 | * |
dc.date.accessioned | 2017-08-25T05:08:42Z | - |
dc.date.available | 2017-08-25T05:08:42Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 1756-4646 | * |
dc.identifier.other | OAK-20580 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/235657 | - |
dc.description.abstract | In this randomized, double-blind, placebo-controlled study, we evaluated the efficacy of Litsea japonica fruit extract (LJF) in subjects with knee osteoarthritis (OA). Eighty-seven 50- to 70-year-old subjects with knee OA were assigned to a placebo group, a low-dose LJF group (LJF-L, 100 mg/d) or a high-dose LJF group (LJF-H, 200 mg/d) for 12 weeks. The outcome measures were pain score assessed using a visual analog scale (VAS); Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores; and blood and urine biomarkers. In response to LJF consumption, VAS scores; WOMAC total scores; WOMAC scores on the pain, stiffness and function subscales; and blood MMP-9 levels significantly improved over the course of the examined 12-week period (P = 0.0001, 0.0102, 0.0293, 0.002, 0.0152 and 0.026, respectively). This study suggests that LJF may reduce joint pain and stiffness and improve joint function in subjects with painful knee OA. Study identifier: KCT0001029 (www.who.int/ictrp/en/). © 2017 Elsevier Ltd | * |
dc.language | English | * |
dc.publisher | Elsevier Ltd | * |
dc.subject | Litsea japonica | * |
dc.subject | MMP-9 | * |
dc.subject | Osteoarthritis | * |
dc.subject | VAS | * |
dc.subject | WOMAC | * |
dc.title | Randomized double-blind placebo-controlled study of the efficacy of Litsea japonica fruit extract in subjects with mild to moderate knee osteoarthritis | * |
dc.type | Article | * |
dc.relation.volume | 34 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 304 | * |
dc.relation.lastpage | 310 | * |
dc.relation.journaltitle | Journal of Functional Foods | * |
dc.identifier.doi | 10.1016/j.jff.2017.05.005 | * |
dc.identifier.wosid | WOS:000403383800033 | * |
dc.identifier.scopusid | 2-s2.0-85018318644 | * |
dc.author.google | Ahn Y. | * |
dc.author.google | Kwon O. | * |
dc.author.google | Kim E.A. | * |
dc.author.google | Yoon W.-J. | * |
dc.author.google | Kim J.H. | * |
dc.author.google | Kim J.Y. | * |
dc.contributor.scopusid | 권오란(55713470100) | * |
dc.date.modifydate | 20240123125010 | * |