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Altered intrinsic brain activity after chemotherapy in patients with gastric cancer: A preliminary study

Title
Altered intrinsic brain activity after chemotherapy in patients with gastric cancer: A preliminary study
Authors
Kim H.G.Shin N.-Y.Bak Y.Kim K.R.Jung Y.-C.Han K.Lee S.-K.Lim S.M.
Ewha Authors
임수미신나영
SCOPUS Author ID
임수미scopus; 신나영scopus
Issue Date
2017
Journal Title
European Radiology
ISSN
0938-7994JCR Link
Citation
vol. 27, no. 7, pp. 2679 - 2688
Keywords
BrainCancer chemotherapy agentsCognitive functionFunctional magnetic resonance imagingGastric cancer
Publisher
Springer Verlag
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Objectives: To characterize the pattern of altered intrinsic brain activity in gastric cancer patients after chemotherapy (CTx). Methods: Patients before and after CTx (n = 14) and control subjects (n = 11) underwent resting-state functional MRI (rsfMRI) at baseline and 3 months after CTx. Regional homogeneity (ReHo), amplitude of low-frequency fluctuation (ALFF), and fractional ALFF (fALFF) were calculated and compared between the groups using the two-sample t test. Correlation analysis was also performed between rsfMRI values (i.e., ReHo, ALFF, and fALFF) and neuropsychological test results. Results: Patients showed poor performance in verbal memory and executive function and decreased rsfMRI values in the frontal areas even before CTx and showed decreased attention/working memory and executive function after CTx compared to the control subjects. In direct comparison of values before and after CTx, there were no significant differences in neuropsychological test scores, but decreased rsfMRI values were observed at the frontal lobes and right cerebellar region. Among rsfMRI values, lower ALFF in the left inferior frontal gyrus was significantly associated with poor performance of the executive function test. Conclusions: We observed decreased attention/working memory and executive function that corresponded to the decline of frontal region activation in gastric cancer patients who underwent CTx. Key Points: • Intrinsic brain activity of gastric cancer patients after chemotherapy was described. • Brain activity and neuropsychological test results were correlated. • Working memory and executive function decreased after chemotherapy. • Decreased cognitive function corresponded to decreased activation of the frontal region. © 2017, European Society of Radiology.
DOI
10.1007/s00330-016-4578-x
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의학전문대학원 > 의학과 > Journal papers
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