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Acrylamide-grafted-acacia gum polymer matrix tablets as erosion-controlled drug delivery systems

Title
Acrylamide-grafted-acacia gum polymer matrix tablets as erosion-controlled drug delivery systems
Authors
Toti U.S.Soppimath K.S.Mallikarjuna N.N.Aminabhavi T.M.
Ewha Authors
Udaya S. Toti
Issue Date
2004
Journal Title
Journal of Applied Polymer Science
ISSN
0021-8995JCR Link
Citation
vol. 93, no. 5, pp. 2245 - 2253
Indexed
SCI; SCIE; SCOPUS scopus
Abstract
Acrylamide was grafted onto acacia gum in different ratios (1 : 1, 1 : 3, and 1 : 5). The graft copolymers formed were characterized by FTIR, rheological measurements, and differential thermal analysis. Tablets were prepared from these polymers loaded with two antihypertensive drugs, viz., diltiazem hydrochloride and nifedipine. The in vitro release experiments were carried out in simulated gastric and intestinal conditions. The graft copolymer prepared in the ratio 1 : 5 of acacia gum : acrylamide matrix was found to be a suitable matrix to investigate the controlled release of diltiazem hydrochloride and nifedipine. The drug release continued up to 6 and 14 h, respectively, for diltiazem hydrochloride and nifedipine. The release mechanism was investigated by using the mathematical equations proposed by Higuchi, Hixson-Crowell, and Kopcha. Based on the release kinetics data, a correlation was attempted between the erosion-controlled release and the dissolution-controlled release. © 2004 Wiley Periodicals, Inc.
DOI
10.1002/app.20768
Appears in Collections:
연구기관 > 나노·바이오기술연구소 > Journal papers
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