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A novel indeno[1,2-b] pyridinone derivative, a DNA intercalative human topoisomerase II alpha catalytic inhibitor, for caspase 3-independent anticancer activity

Title
A novel indeno[1,2-b] pyridinone derivative, a DNA intercalative human topoisomerase II alpha catalytic inhibitor, for caspase 3-independent anticancer activity
Authors
Jeon, K. H.Park, C.Kadayat, T. M.Shrestha, A.Lee, E. S.Kwon, Y.
Ewha Authors
권영주
SCOPUS Author ID
권영주scopus
Issue Date
2017
Journal Title
CHEMICAL COMMUNICATIONS
ISSN
1359-7345JCR Link1364-548XJCR Link
Citation
vol. 53, no. 51
Publisher
ROYAL SOC CHEMISTRY
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
A novel 2-(furan-2-yl)-4-(pyridin-2-yl)-5H-indeno[1,2-b] pyridin-5-one (TI-1-190) was synthesized using a simple microwave-assisted method and its mode of action was systematically characterized. It is a DNA intercalative human topoisomerase II alpha catalytic inhibitor with much stronger activity and less DNA toxicity than etoposide, a topoisomerase II poison. TI-1-190 displays caspase 3-independent anticancer activity, unlike etoposide.
DOI
10.1039/c7cc02372c
Appears in Collections:
약학대학 > 약학과 > Journal papers
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