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Effects of Adrenal Androgen Levels on Bone Age Advancement in Prepubertal Children: Using the Ewha Birth and Growth Cohort Study
- Effects of Adrenal Androgen Levels on Bone Age Advancement in Prepubertal Children: Using the Ewha Birth and Growth Cohort Study
- Kwon, Jung Hyun; Lee, Hye Ah; Kim, Young Ju; Lee, Hwayoung; Park, Eun Ae; Cho, Su Jin; Gwak, Hye Sun; Ha, Eunhee; Park, Hyesook; Kim, Hae Soon
- Ewha Authors
- 김영주; 김혜순; 이화영; 조수진
- SCOPUS Author ID
- 김영주; 김혜순; 이화영; 조수진
- Issue Date
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- 1011-8934; 1598-6357
- vol. 32, no. 6, pp. 968 - 973
- Adrenal Cortex Hormone; Bone Age; Children; Obesity
- KOREAN ACAD MEDICAL SCIENCES
- SCI; SCIE; SCOPUS; KCI
- Bone age (BA) advancement in prepubertal children may be associated with earlier onset of puberty and obesity. This study aimed to define the effects of adrenal androgen levels on the advancement of BA in prepubertal children, independent of obesity. During July and August 2011, we examined BA in 200 prepubertal children aged 7-9 years who were part of the Ewha Birth & Growth Cohort Study. BA was assessed by the Greulich-Pyle method. An index of BA advancement was calculated as the ratio of BA to chronological age (CA) (BA/CA), and this ratio was classified into 3 tertiles. We analyzed the relationship between BA advancement and anthropometric characteristics and adrenal hormone levels. The number of overweight children increased from the first group to the third group (P-Trend = 0.03). The levels of adrenal androgens showed a significant positive correlation with the tertile groups after adjusting for age and sex (testosterone: r = 0.26, P < 0.001; dehydroepiandrosterone: r = 0.21, P < 0.001; androstenedione: r = 0.20, P < 0.001). Further, after controlling for body mass index (BMI), sex, and age, the BA/CA was found to be positively correlated with androstenedione (beta = 0.04, R-2 = 3.7%) and testosterone levels (beta = 0.05, R-2 = 4.7%). Based on our results, it is suggested that adrenal androgen levels are associated with BA advancement independent of BMI.
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- 의학전문대학원 > 의학과 > Journal papers
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