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Effects of Adrenal Androgen Levels on Bone Age Advancement in Prepubertal Children: Using the Ewha Birth and Growth Cohort Study

Title
Effects of Adrenal Androgen Levels on Bone Age Advancement in Prepubertal Children: Using the Ewha Birth and Growth Cohort Study
Authors
Kwon, Jung HyunLee, Hye AhKim, Young JuLee, HwayoungPark, Eun AeCho, Su JinGwak, Hye SunHa, EunheePark, HyesookKim, Hae Soon
Ewha Authors
김영주김혜순이화영조수진
SCOPUS Author ID
김영주scopus; 김혜순scopus; 이화영scopus; 조수진scopus
Issue Date
2017
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
ISSN
1011-8934JCR Link1598-6357JCR Link
Citation
vol. 32, no. 6, pp. 968 - 973
Keywords
Adrenal Cortex HormoneBone AgeChildrenObesity
Publisher
KOREAN ACAD MEDICAL SCIENCES
Indexed
SCI; SCIE; SCOPUS; KCI WOS
Abstract
Bone age (BA) advancement in prepubertal children may be associated with earlier onset of puberty and obesity. This study aimed to define the effects of adrenal androgen levels on the advancement of BA in prepubertal children, independent of obesity. During July and August 2011, we examined BA in 200 prepubertal children aged 7-9 years who were part of the Ewha Birth & Growth Cohort Study. BA was assessed by the Greulich-Pyle method. An index of BA advancement was calculated as the ratio of BA to chronological age (CA) (BA/CA), and this ratio was classified into 3 tertiles. We analyzed the relationship between BA advancement and anthropometric characteristics and adrenal hormone levels. The number of overweight children increased from the first group to the third group (P-Trend = 0.03). The levels of adrenal androgens showed a significant positive correlation with the tertile groups after adjusting for age and sex (testosterone: r = 0.26, P < 0.001; dehydroepiandrosterone: r = 0.21, P < 0.001; androstenedione: r = 0.20, P < 0.001). Further, after controlling for body mass index (BMI), sex, and age, the BA/CA was found to be positively correlated with androstenedione (beta = 0.04, R-2 = 3.7%) and testosterone levels (beta = 0.05, R-2 = 4.7%). Based on our results, it is suggested that adrenal androgen levels are associated with BA advancement independent of BMI.
DOI
10.3346/jkms.2017.32.6.968
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의과대학 > 의학과 > Journal papers
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