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Ratio of Autoantibodies of Tumor Suppressor AIMP2 and Its Oncogenic Variant Is Associated with Clinical Outcome in Lung Cancer

Title
Ratio of Autoantibodies of Tumor Suppressor AIMP2 and Its Oncogenic Variant Is Associated with Clinical Outcome in Lung Cancer
Authors
Jung, Ji YeKim, Eun YoungKim, ArumChang, JoonKwon, Nam HoonMoon, YoungjiKang, Eun JooSung, Jun SikShim, HyunboKim, SunghoonChang, Yoon Soo
Ewha Authors
심현보
SCOPUS Author ID
심현보scopus
Issue Date
2017
Journal Title
JOURNAL OF CANCER
ISSN
1837-9664JCR Link
Citation
vol. 8, no. 8, pp. 1347 - 1354
Keywords
Aminoacyl t-RNA synthetase (ARS)Aminoacyl t-RNA synthetase-interacting multi-functionalprotein 2 (AIMP2)Aminoacyl t-RNA synthetase-interacting multi-functional protein 2-exon 2 deletion (AIMP2-DX2)AutoantibodyLung cancer
Publisher
IVYSPRING INT PUBL
Indexed
SCIE; SCOPUS WOS
Abstract
Aminoacyl-tRNA synthetase-interacting multi-functional protein 2 (AIMP2) works as potent tumor suppressor, while its splicing variant lacking exon 2 (AIMP2-DX2) competes with AIMP2 for binding to target proteins and compromises its anti-tumor activity. Assuming that AIMP2 and its variant AIMP2-DX2 could be released out to human sera in pathological condition, we investigated the diagnostic and prognostic usefulness of autoantibodies against AIMP2 and AIMP2-DX2 by measuring their serum levels in 80 normal and lung cancer samples that were matched in age, gender and smoking status. The area under the curve of AIMP2-DX2, AIMP2, and AIMP2-DX2/AIMP2 autoantibody ratio was low (0.416, 0.579, and 0.357, respectively), suggesting limited diagnostic value. A total of 165 lung cancer patients were classified into low and high AIMP2-DX2, AIMP2, and AIMP2-DX2/AIMP2 based on the median expression of each parameter. The high AIMP2-DX2 group was older and had larger tumors (>3 cm) than the low AIMP2-DX2 group. The high AIMP2-DX2/AIMP2 group had higher CYFRA-21 levels and significantly shorter overall survival than the low AIMP2-DX2/AIMP2 group (18.6 vs. 48.9 months, P = 0.021, Log Rank Test). Taken together, autoantibodies against AIMP2-DX2 and AIMP2 are detectable in the human blood and the increased ratio of AIMP2-DX2/AIMP2 is related to poor clinical outcome of lung cancer.
DOI
10.7150/jca.18450
Appears in Collections:
일반대학원 > 바이오융합과학과 > Journal papers
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