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Association of Gestational Weight Gain With Maternal and Infant Outcomes A Systematic Review and Meta-analysis

Title
Association of Gestational Weight Gain With Maternal and Infant Outcomes A Systematic Review and Meta-analysis
Authors
Goldstein, Rebecca F.Abell, Sally K.Ranasinha, SanjeevaMisso, MarieBoyle, Jacqueline A.Black, Mary HelenLi, NanHu, GangCorrado, FrancescoRode, LineKim, Young JuHaugen, MargarethaSong, Won O.Kim, Min HyoungBogaerts, AnnickDevlieger, RolandChung, Judith H.Teede, Helena J.
Ewha Authors
김영주
SCOPUS Author ID
김영주scopus
Issue Date
2017
Journal Title
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
ISSN
0098-7484JCR Link

1538-3598JCR Link
Citation
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION vol. 317, no. 21, pp. 2207 - 2225
Publisher
AMER MEDICAL ASSOC
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Review
Abstract
IMPORTANCE Body mass index (BMI) and gestational weight gain are increasing globally. In 2009, the Institute of Medicine (IOM) provided specific recommendations regarding the ideal gestational weight gain. However, the association between gestational weight gain consistent with the IOM guidelines and pregnancy outcomes is unclear. OBJECTIVE To perform a systematic review, meta-analysis, and metaregression to evaluate associations between gestational weight gain above or below the IOM guidelines (gain of 12.5-18 kg for underweight women [BMI <18.5]; 11.5-16 kg for normal-weight women [BMI 18.5-24.9]; 7-11 kg for overweight women [BMI 25-29.9]; and 5-9 kg for obese women [BMI >= 30]) and maternal and infant outcomes. DATA SOURCES AND STUDY SELECTION Search of EMBASE, Evidence-Based Medicine Reviews, MEDLINE, and MEDLINE In-Process between January 1, 1999, and February 7, 2017, for observational studies stratified by prepregnancy BMI category and total gestational weight gain. DATA EXTRACTION AND SYNTHESIS Data were extracted by 2 independent reviewers. Odds ratios (ORs) and absolute risk differences (ARDs) per live birth were calculated using a random-effects model based on a subset of studies with available data. MAIN OUTCOMES AND MEASURES Primary outcomes were small for gestational age (SGA), preterm birth, and large for gestational age (LGA). Secondary outcomes were macrosomia, cesarean delivery, and gestational diabetes mellitus. RESULTS Of 5354 identified studies, 23 (n = 1 309 136 women) met inclusion criteria. Gestational weight gain was below or above guidelines in 23% and 47% of pregnancies, respectively. Gestational weight gain below the recommendations was associated with higher risk of SGA (OR, 1.53 [95% CI, 1.44-1.64]; ARD, 5%[95% CI, 4%-6%]) and preterm birth (OR, 1.70 [1.32-2.20]; ARD, 5%[3%-8%]) and lower risk of LGA (OR, 0.59 [0.55-0.64]; ARD, -2% [-10% to -6%]) and macrosomia (OR, 0.60 [0.52-0.68]; ARD, -2%[-3% to -1%]); cesarean delivery showed no significant difference (OR, 0.98 [0.96-1.02]; ARD, 0%[-2% to 1%]). Gestational weight gain above the recommendations was associated with lower risk of SGA (OR, 0.66 [0.63-0.69]; ARD, -3%; [-4% to -2%]) and preterm birth (OR, 0.77 [0.69-0.86]; ARD, -2%[-2% to -1%]) and higher risk of LGA (OR, 1.85 [1.76-1.95]; ARD, 4%[2%-5%]), macrosomia (OR, 1.95 [1.79-2.11]; ARD, 6%[4%-9%]), and cesarean delivery (OR, 1.30 [1.25-1.35]; ARD, 4%[3%-6%]). Gestational diabetes mellitus could not be evaluated because of the nature of available data. CONCLUSIONS AND RELEVANCE In this systematic review andmeta-analysis of more than 1 million pregnant women, 47% had gestational weight gain greater than IOM recommendations and 23% had gestational weight gain less than IOM recommendations. Gestational weight gain greater than or less than guideline recommendations, compared with weight gain within recommended levels, was associated with higher risk of adverse maternal and infant outcomes.
DOI
10.1001/jama.2017.3635
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의과대학 > 의학과 > Journal papers
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