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Prediction of the Seizure Suppression Effect by Electrical Stimulation via a Computational Modeling Approach

Title
Prediction of the Seizure Suppression Effect by Electrical Stimulation via a Computational Modeling Approach
Authors
Ahn, SoraJo, SuminJun, Sang BeomLee, Hyang WoonLee, Seungjun
Ewha Authors
이승준이향운전상범
SCOPUS Author ID
이승준scopus; 이향운scopus; 전상범scopus
Issue Date
2017
Journal Title
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
ISSN
1662-5188JCR Link
Citation
vol. 11
Keywords
seizure suppressionelectrical stimulationcomputational modelin vitro experimentseizure propagation mechanismelectrical field effect
Publisher
FRONTIERS MEDIA SA
Indexed
SCIE; SCOPUS WOS
Abstract
In this paper, we identified factors that can affect seizure suppression via electrical stimulation by an integrative study based on experimental and computational approach. Preferentially, we analyzed the characteristics of seizure-like events (SLEs) using our previous invitro experimental data. The results were analyzed in two groups classified according to the size of the effective region, in which the SLE was able to be completely suppressed by local stimulation. However, no significant differences were found between these two groups in terms of signal features or propagation characteristics (i.e., propagation delays, frequency spectrum, and phase synchrony). Thus, we further investigated important factors using a computational model that was capable of evaluating specific influences on effective region size. In the proposed model, signal transmission between neurons was based on two different mechanisms: synaptic transmission and the electrical field effect. We were able to induce SLEs having similar characteristics with differentially weighted adjustments for the two transmission methods in various noise environments. Although the SLEs had similar characteristics, their suppression effects differed. First of all, the suppression effect occurred only locally where directly received the stimulation effect in the high noise environment, but it occurred in the entire network in the low noise environment. Interestingly, in the same noise environment, the suppression effect was different depending on SLE propagation mechanism; only a local suppression effect was observed when the influence of the electrical field transmission was very weak, whereas a global effect was observed with a stronger electrical field effect. These results indicate that neuronal activities synchronized by a strong electrical field effect respond more sensitively to partial changes in the entire network. In addition, the proposed model was able to predict that stimulation of a seizure focus region is more effective for suppression. In conclusion, we confirmed the possibility of a computational model as a simulation tool to analyze the efficacy of deep brain stimulation (DBS) and investigated the key factors that determine the size of an effective region in seizure suppression via electrical stimulation.
DOI
10.3389/fncom.2017.00039
Appears in Collections:
엘텍공과대학 > 전자공학과 > Journal papers
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