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Vaginal Brenner tumor with literature review: does this tumour originate from Walthard nests?

Title
Vaginal Brenner tumor with literature review: does this tumour originate from Walthard nests?
Authors
Park, SanghuiCho, Min-Sun
Ewha Authors
조민선박상희
SCOPUS Author ID
조민선scopus; 박상희scopus
Issue Date
2017
Journal Title
MALAYSIAN JOURNAL OF PATHOLOGY
ISSN
0126-8635JCR Link
Citation
vol. 39, no. 1, pp. 89 - 93
Keywords
Brenner tumourvaginaWalthard nest
Publisher
MALAYSIAN JOURNAL PATHOLOGY
Indexed
SCIE; SCOPUS WOS
Abstract
Vaginal Brenner tumor is extremely rare. Only five cases have been reported in the English literature to date. Here we report a vaginal Brenner tumor in a 76-year old postmenopausal woman, who presented with a 2.5cm-sized sessile vaginal polyp. Microscopically, it showed characteristic features of Brenner tumor consisting of three components; transitional islands, glands, and dense fibrous stroma. The epithelial tumor cells were positive for GATA-3, p63 and ER, but negative for PAX8. The origin of Brenner tumors in the vagina is unclear, but previous reports suggested of Mullerian origin. However, our case revealed that vaginal Walthard nests could be possible precursor lesions based on their immunohistochemical staining results.
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의과대학 > 의학과 > Journal papers
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