View : 24 Download: 2

Acute high-dose and chronic lifetime exposure to alcohol consumption and differentiated thyroid cancer: T-CALOS Korea

Title
Acute high-dose and chronic lifetime exposure to alcohol consumption and differentiated thyroid cancer: T-CALOS Korea
Authors
Hwang Y.Lee K.E.Weiderpass E.Park Y.J.Chai Y.J.Kwon H.Park D.J.Cho B.Choi H.-C.Kang D.Park S.K.
Ewha Authors
권형주
SCOPUS Author ID
권형주scopus
Issue Date
2016
Journal Title
PLoS ONE
ISSN
1932-6203JCR Link
Citation
vol. 11, no. 3
Publisher
Public Library of Science
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Background: This study evaluated the effects of acute high-dose and chronic lifetime exposure to alcohol and exposure patterns on the development of differentiated thyroid cancer (DTC). Methods: The Thyroid Cancer Longitudinal Study (T-CALOS) included 2,258 DTC patients (449 men and 1,809 women) and 22,580 healthy participants (4,490 men and 18,090 women) who were individually matched by age, gender, and enrollment year. In-person interviews were conducted with a structured questionnaire to obtain epidemiologic data. Clinicopathologic features of the patients were obtained by chart reviews. Odds ratios (ORs) and 95% confidence intervals (95%CI) were estimated using conditional regression models. Results: While light or moderate drinking behavior was related to a reduced risk of DTC, acute heavy alcohol consumption (151 g or more per event or on a single occasion) was associated with increased risks in men (OR = 2.22, 95%CI = 1.27-3.87) and women (OR = 3.61, 95%CI = 1.52-8.58) compared with never-drinkers. The consumption of alcohol for 31 or more years was a significant risk factor for DTC for both men (31-40 years: OR = 1.58, 95%CI = 1.10-2.28; 41+ years: OR = 3.46, 95%CI = 2.06-5.80) and women (31-40 years: OR = 2.18, 95%CI = 1.62-2.92; 41+ years: OR = 2.71, 95%CI = 1.36-5.05) compared with never-drinkers. The consumption of a large amount of alcohol on a single occasion was also a significant risk factor, even after restricting DTC outcomes to tumor size, lymph node metastasis, extrathyroidal extension and TNM stage. Conclusion: The findings of this study suggest that the threshold effects of acute high-dose alcohol consumption and long-term alcohol consumption are linked to an increased risk of DTC. © 2016 Hwang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI
10.1371/journal.pone.0151562
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
Acute High-Dose and Chronic Lifetime.pdf(231.62 kB)Download
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE