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Exploiting virus-like particles as innovative vaccines against emerging viral infections

Title
Exploiting virus-like particles as innovative vaccines against emerging viral infections
Authors
Jeong, HotcherlSeong, Baik Lin
Ewha Authors
정호철
SCOPUS Author ID
정호철scopus
Issue Date
2017
Journal Title
JOURNAL OF MICROBIOLOGY
ISSN
1225-8873JCR Link1976-3794JCR Link
Citation
vol. 55, no. 3, pp. 220 - 230
Keywords
virus-like particlesemerging virusesexpression systemsvaccine designdownstream processes
Publisher
MICROBIOLOGICAL SOCIETY KOREA
Indexed
SCIE; SCOPUS; KCI WOS
Abstract
Emerging viruses pose a major threat to humans and livestock with global public health and economic burdens. Vaccination remains an effective tool to reduce this threat, and yet, the conventional cell culture often fails to produce sufficient vaccine dose. As an alternative to cell-culture based vaccine, virus-like particles (VLPs) are considered as a highpriority vaccine strategy against emerging viruses. VLPs represent highly ordered repetitive structures via macromolecular assemblies of viral proteins. The particulate nature allows efficient uptake into antigen presenting cells stimulating both innate and adaptive immune responses towards enhanced vaccine efficacy. Increasing research activity and translation opportunity necessitate the advances in the design of VLPs and new bioprocessing modalities for efficient and cost-effective production. Herein, we describe major achievements and challenges in this endeavor, with respect to designing strategies to harnessing the immunogenic potential, production platforms, downstream processes, and some exemplary cases in developing VLP-based vaccines.
DOI
10.1007/s12275-017-7058-3
Appears in Collections:
약학대학 > 약학과 > Journal papers
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