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Glutathione alleviated peripheral neuropathy in oxaliplatin-treated mice by removing aluminum from dorsal root ganglia

Title
Glutathione alleviated peripheral neuropathy in oxaliplatin-treated mice by removing aluminum from dorsal root ganglia
Authors
Lee, MinjiCho, SungraeRoh, KangsanChae, JisookPark, Jin-HeePark, JaehyunLee, Myung-AhKim, JinheungAuh, Chung-KyoonYeom, Chang-HwanLee, Sukchan
Ewha Authors
김진흥
SCOPUS Author ID
김진흥scopus
Issue Date
2017
Journal Title
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
ISSN
1943-8141JCR Link
Citation
vol. 9, no. 3, pp. 926 - 939
Keywords
Aluminumglutathioneperipheral neuropathyoxaliplatinTRPA1
Publisher
E-CENTURY PUBLISHING CORP
Indexed
SCIE; SCOPUS WOS
Abstract
Oxaliplatin, a platinum-based anti-cancer drug, induces peripheral neuropathy as a side effect and causes cold hyperalgesia in cancer patients receiving anti-cancer chemotherapy. In oxaliplatin-treated mice, aluminum was accumulated in the dorsal root ganglia (DRG), and accumulated aluminum in DRG or other organs aggravated oxaliplatin- induced neuropathic pain. To investigate whether aluminum oxalate, which is the compound of aluminum and oxaliplatin, might be the peripheral neuropathy inducer, the withdrawal responses of mice to coldness, the expression of transient receptor potential ankyrin 1 and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assays in DRG were analyzed in mice administered with aluminum oxalate. In addition, the concentrations of aluminum in aluminum oxalate-treated mice were significantly increased compared to those of mice treated with aluminum chloride. To alleviate neuropathic pain, glutathione (GSH), known as an antioxidant and a metal chelator, was injected into oxaliplatin-treated mice. The concentrations of aluminum in the DRG were decreased by the chelation action of GSH. Taken together, behavioral and molecular analyses also supported that aluminum accumulation on the DRG might be a factor for neuropathic pain. This result also suggested that the aluminum chelation by GSH can provide an alleviatory remedy of neuropathic pain for cancer patients with oxaliplatin-induced neuropathic pain.
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자연과학대학 > 화학·나노과학전공 > Journal papers
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