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Engineered microbial biosensors based on bacterial two-component systems as synthetic biotechnology platforms in bioremediation and biorefinery

Title
Engineered microbial biosensors based on bacterial two-component systems as synthetic biotechnology platforms in bioremediation and biorefinery
Authors
Ravikumar, SambandamBaylon, Mary GracePark, Si JaeChoi, Jong-il
Ewha Authors
박시재
SCOPUS Author ID
박시재scopus
Issue Date
2017
Journal Title
MICROBIAL CELL FACTORIES
ISSN
1475-2859JCR Link
Citation
vol. 16
Keywords
Two-component regulatory systemBiosensorBioremediationGenetic circuitBiorefinery
Publisher
BIOMED CENTRAL LTD
Indexed
SCIE; SCOPUS WOS
Abstract
Two-component regulatory systems (TCRSs) mediate cellular response by coupling sensing and regulatory mechanisms. TCRSs are comprised of a histidine kinase (HK), which serves as a sensor, and a response regulator, which regulates expression of the effector gene after being phosphorylated by HK. Using these attributes, bacterial TCRSs can be engineered to design microbial systems for different applications. This review focuses on the current advances in TCRS-based biosensors and on the design of microbial systems for bioremediation and their potential application in biorefinery.
DOI
10.1186/s12934-017-0675-z
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엘텍공과대학 > 화학신소재공학전공 > Journal papers
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