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Anosognosia and Its Relation to Psychiatric Symptoms in Early-Onset Alzheimer Disease

Title
Anosognosia and Its Relation to Psychiatric Symptoms in Early-Onset Alzheimer Disease
Authors
Yoon, BoraShim, Yong S.Hong, Yun JeongChoi, Seong HyePark, Hee KyungPark, Sun AhJeong, Jee HyangYoon, Soo JinYang, Dong-Won
Ewha Authors
정지향
SCOPUS Author ID
정지향scopus
Issue Date
2017
Journal Title
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
ISSN
0891-9887JCR Link1552-5708JCR Link
Citation
vol. 30, no. 3, pp. 170 - 177
Keywords
Alzheimer diseaseearly-onsetanosognosiainsightNeuropsychiatric InventoryClinical Dementia Rating
Publisher
SAGE PUBLICATIONS INC
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
Background: We investigated differences in the prevalence of anosognosia and neuropsychiatric symptoms (NPSs) characteristics according to disease severity in patients with early-onset Alzheimer disease (EOAD). Methods: We recruited 616 patients with EOAD. We subdivided participants into 2 groups based on the presence or absence of anosognosia and then again by Clinical Dementia Rating (CDR) scale. We compared the differences in the Neuropsychiatric Inventory (NPI) scores according to anosognosia and disease severity. Results: The percentage of patients with anosognosia in each CDR group steadily increased as the CDR rating increased (CDR 0.5 8.6% vs CDR 1 13.6% vs CDR 2 26.2%). The NPI total score was significantly higher in patients with anosognosia in the CDR 0.5 and 1 groups; by contrast, it had no association in the CDR 2 group. Frontal lobe functions were associated with anosognosia only in the CDR 0.5 and 1 groups. After stratification by CDR, in the CDR 0.5 group, the prevalence of agitation (P = .040) and appetite (P = .013) was significantly higher in patients with anosognosia. In the CDR 1 group, patients with anosognosia had a significantly higher prevalence of delusions (P = .032), hallucinations (P = .048), and sleep disturbances (P = .047). In the CDR 2 group, we found no statistical difference in the frequency of symptoms between patients with and without anosognosia. Conclusion: These results confirm that the prevalence of anosognosia as well as the individual NPS and cognitive functions associated with it differ according to EOAD severity.
DOI
10.1177/0891988717700508
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의학전문대학원 > 의학과 > Journal papers
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