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Fine-tuning of gene expression dynamics by the Set2-Rpd3S pathway

Title
Fine-tuning of gene expression dynamics by the Set2-Rpd3S pathway
Authors
Lee, Bo BaeKim, Ji HyunKim, TaeSoo
Ewha Authors
김태수
SCOPUS Author ID
김태수scopus
Issue Date
2017
Journal Title
BMB REPORTS
ISSN
1976-6696JCR Link1976-670XJCR Link
Citation
vol. 50, no. 4, pp. 162 - 163
Keywords
Gene expression dynamicsH3K36 methylationHistone deacetylationRpd3S HDACSet2
Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Indexed
SCIE; SCOPUS; KCI WOS
Abstract
RNA polymerase II-interacting the Set2 methyltransferase co-transcriptionally methylates histone H3 at lysine 36 within the body of genes. This modification facilitates histone deacetylation by Rpd3S HDAC in 3' transcribed regions to suppress cryptic initiation and slow elongation. Although this pathway is important for global deacetylation, no strong effects have been seen on genome-wide transcription under optimized laboratory conditions. In contrast, this pathway slows the kinetics of mRNA induction when target genes are induced upon environmental changes. Interestingly, a majority of Set2-repressed genes are overlapped by a lncRNA transcription that targets H3K36 methylation and deacetylation by Rpd3S HDAC to mRNA promoters. Furthermore, this pathway delays the induction of many cryptic transcripts upon environmental changes. Therefore, the Set2-Rpd3S HDAC pathway functions to fine-tune expression dynamics of mRNAs and ncRNAs.
DOI
10.5483/BMBRep.2017.50.4.049
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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