Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이정은 | - |
dc.date.accessioned | 2017-06-13T01:06:12Z | - |
dc.date.available | 2017-06-13T01:06:12Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1226-3303 | - |
dc.identifier.issn | 2005-6648 | - |
dc.identifier.other | OAK-20687 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/235251 | - |
dc.description.abstract | Background/Aims: Multiple myeloma (MM)-associated cardiac damage, particularly according to the type of monoclonal (M) protein has not been elucidated. We sought to investigate relationship between elevated serum M protein levels and echocardiographic indices of cardiac structure and function in patients with MM. Methods: We evaluated a total of 184 consecutive MM patients who underwent echocardiography for bone marrow pre-transplant screening. Serum levels of intact immunoglobulin M protein and free light chain kappa/lambda (FLC-kappa/-lambda) were measured. Results: One hundred thirty-nine patients were non-light chain MM (non-LCMM) and 45 patients belonged to LCMM. In patients with non-LCMM, significant correlations were found between serum M protein and left atrial volume index (LAVi; r = 0.720, p < 0.0001), E/e' (r = 0.511, p < 0.0001), and systolic pulmonary arterial pressure (r = 0.485, p < 0.0001). In patients with LCMM, log-transformed FLC-lambda (log-lambda) was correlated with left ventricular ejection fraction (LVEF, r = -0.536, p = 0.010), left ventricular (LV) end-systolic dimension (r = 0.500, p = 0.018), and LV end-systolic volume (r = 0.444, p = 0.038). On multivariate analyses, hematocrit and serum M protein were independent predictors of LAVi in patients with non-LCMM. In patient with LCMM, FLC-lambda isotype was only found to be an independent determinant of LVEF. Conclusions: An increase in serum M protein was associated with LV diastolic dysfunction, whereas an increase in serum FLC-lambda concentration showed a negative correlation with the echocardiographic parameters of LV systolic function. These findings also suggest that serum M protein has different effects on LV function according to the type of paraproteins in patients with MM. | - |
dc.language | English | - |
dc.publisher | KOREAN ASSOC INTERNAL MEDICINE | - |
dc.subject | Multiple myeloma | - |
dc.subject | Serum monoclonal paraprotein | - |
dc.subject | Ventricular function, left | - |
dc.title | Association between left ventricular function and paraprotein type in patients with multiple myeloma | - |
dc.type | Article | - |
dc.relation.issue | 3 | - |
dc.relation.volume | 32 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 459 | - |
dc.relation.lastpage | 468 | - |
dc.relation.journaltitle | KOREAN JOURNAL OF INTERNAL MEDICINE | - |
dc.identifier.doi | 10.3904/kjim.2015.339 | - |
dc.identifier.wosid | WOS:000401013600010 | - |
dc.identifier.scopusid | 2-s2.0-85019954910 | - |
dc.author.google | Yi, Jeong-Eun | - |
dc.author.google | Lee, Sung-Eun | - |
dc.author.google | Jung, Hae-Ok | - |
dc.author.google | Min, Chang-Ki | - |
dc.author.google | Youn, Ho-Joong | - |
dc.contributor.scopusid | 이정은(16308471000) | - |
dc.date.modifydate | 20190309081001 | - |