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Confinement-driven organization of a histone-complexed DNA molecule in a dense array of nanoposts

Title
Confinement-driven organization of a histone-complexed DNA molecule in a dense array of nanoposts
Authors
Joo H.Kim J.S.
Ewha Authors
김준수
SCOPUS Author ID
김준수scopus
Issue Date
2017
Journal Title
Nanoscale
ISSN
2040-3364JCR Link
Citation
vol. 9, no. 19, pp. 6391 - 6398
Publisher
Royal Society of Chemistry
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The first step in the controlled storage of lengthy DNA molecules is to keep DNA molecules separated while integrated in micrometer-sized space. Herein, we present hybrid Monte Carlo simulations of a histone-complexed DNA (hcDNA) molecule confined in a dense array of nanoposts. Depending on the nanopost dimension, a single, 8.7 kilobase pair hcDNA molecule was either localized and elongated in a single inter-post space surrounded by four nanoposts or spread over several inter-post spaces through passages between two neighboring nanoposts. The conformational change of a hcDNA molecule is interpreted in terms of competitive effects of confinements in the inter-post and passage spaces. We propose that, by elaborately designing nanopost arrays, the competitive confinement effects can be adjusted such that each hcDNA molecule is localized in a single inter-post space, and thereby multiple hcDNA molecules can be physically separated from each other while stored together in the nanopost array. © 2017 The Royal Society of Chemistry.
DOI
10.1039/c7nr00859g
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자연과학대학 > 화학·나노과학전공 > Journal papers
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