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Technological development of structural DNA/RNA-based RNAi systems and their applications

Title
Technological development of structural DNA/RNA-based RNAi systems and their applications
Authors
Jeong, Eun HyeKim, HyejinJang, BoraCho, HyesooRyu, JaeheeKim, BoyeonPark, YoungkukKim, JieunLee, Jong BumLee, Hyukjin
Ewha Authors
이혁진
SCOPUS Author ID
이혁진scopus
Issue Date
2016
Journal Title
ADVANCED DRUG DELIVERY REVIEWS
ISSN
0169-409XJCR Link1872-8294JCR Link
Citation
vol. 104, pp. 29 - 43
Keywords
RNAisiRNANanotechnologyStructural DNA/RNA
Publisher
ELSEVIER SCIENCE BV
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
RNA interference (RNAi)-based gene therapy has drawn tremendous attention due to its highly specific gene regulation by selective degradation of any target mRNA. There have been multiple reports regarding the development of various cationic materials for efficient siRNA delivery, however, many studies still suffer from the conventional delivery problems such as suboptimal transfection performance, a lack of tissue specificity, and potential cytotoxicity. Despite the huge therapeutic potential of siRNAs, conventional gene carriers have failed to guarantee successful gene silencing in vivo, thus not warranting clinical trials. The relatively short double stranded structure of siRNAs has resulted in uncompromising delivery formulations, as well as low transfection efficiency, compared with the conventional nucleic acid drugs such as plasmid DNAs. Recent developments in structural siRNA and RNAi nanotechnology have enabled more refined and reliable in vivo gene silencing with multiple advantages over naked siRNAs. This review focuses on recent progress in the development of structural DNA/RNA-based RNAi systems and their potential therapeutic applications. In addition, an extensive list of prior reports on various RNAi systems is provided and categorized by their distinctive molecular characters. (C) 2015 Elsevier B.V. All rights reserved.
DOI
10.1016/j.addr.2015.10.008
Appears in Collections:
약학대학 > 약학과 > Journal papers
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