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Platelet Shape Changes and Cytoskeleton Dynamics as Novel Therapeutic Targets for Anti-Thrombotic Drugs

Title
Platelet Shape Changes and Cytoskeleton Dynamics as Novel Therapeutic Targets for Anti-Thrombotic Drugs
Authors
Shin, Eun-KyungParke, HanseulNoh, Ji-YoonLim, Kyung-MinChung, Jin-Ho
Ewha Authors
임경민
SCOPUS Author ID
임경민scopus
Issue Date
2017
Journal Title
BIOMOLECULES & THERAPEUTICS
ISSN
1976-9148JCR Link2005-4483JCR Link
Citation
vol. 25, no. 3, pp. 223 - 230
Keywords
Platelet shape changesCytoskeleton dynamicsThrombosisAggregationAdhesion
Publisher
KOREAN SOC APPLIED PHARMACOLOGY
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Platelets play an essential role in hemostasis through aggregation and adhesion to vascular injury sites but their unnecessary activation can often lead to thrombotic diseases. Upon exposure to physical or biochemical stimuli, remarkable platelet shape changes precede aggregation or adhesion. Platelets shape changes facilitate the formation and adhesion of platelet aggregates, but are readily reversible in contrast to the irrevocable characteristics of aggregation and adhesion. In this dynamic phenomenon, complex molecular signaling pathways and a host of diverse cytoskeleton proteins are involved. Platelet shape change is easily primed by diverse pro-thrombotic xenobiotics and stimuli, and its inhibition can modulate thrombosis, which can ultimately contribute to the development or prevention of thrombotic diseases. In this review, we discussed the current knowledge on the mechanisms of platelet shape change and also pathological implications and therapeutic opportunities for regulating the related cytoskeleton dynamics.
DOI
10.4062/biomolther.2016.138
Appears in Collections:
약학대학 > 약학과 > Journal papers
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