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Th17 cell-mediated immune responses promote mast cell proliferation by triggering stem cell factor in keratinocytes

Title
Th17 cell-mediated immune responses promote mast cell proliferation by triggering stem cell factor in keratinocytes
Authors
Cho K.-A.Park M.Kim Y.-H.Woo S.-Y.
Ewha Authors
우소연김유희조경아
SCOPUS Author ID
우소연scopus; 김유희scopus; 조경아scopus
Issue Date
2017
Journal Title
Biochemical and Biophysical Research Communications
ISSN
0006-291XJCR Link
Citation
vol. 487, no. 4, pp. 856 - 861
Keywords
KeratinocyteMast cellPsoriasisStem cell factor
Publisher
Elsevier B.V.
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Although mast cells are traditionally thought to function as effector cells in allergic responses, they have increasingly been recognized as important regulators of various immune responses. Mast cells mature locally; thus, tissue-specific influences are important for promoting mast cell accumulation and survival in the skin and the gastrointestinal tract. In this study, we determined the effects of keratinocytes on mast cell accumulation during Th17-mediated skin inflammation. We observed increases in dermal mast cells in imiquimod-induced psoriatic dermatitis in mice accompanied by the expression of epidermal stem cell factor (SCF), a critical mast cell growth factor. Similar to mouse epidermal keratinocytes, SCF was highly expressed in the human HaCaT keratinocyte cell line following stimulation with IL−17. Further, keratinocytes promoted mast cell proliferation following stimulation with IL−17 in vitro. However, the effects of keratinocytes on mast cells were significantly diminished in the presence of anti−CD117 (stem cell factor receptor) blocking antibodies. Taken together, our results revealed that the Th17-mediated inflammatory environment promotes mast cell accumulation through keratinocyte-derived SCF. © 2017 Elsevier Inc.
DOI
10.1016/j.bbrc.2017.04.141
Appears in Collections:
의과대학 > 의학과 > Journal papers
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