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Cacao Polyphenols Potentiate Anti-Platelet Effect of Endothelial Cells and Ameliorate Hypercoagulatory States Associated with Hypercholesterolemia

Title
Cacao Polyphenols Potentiate Anti-Platelet Effect of Endothelial Cells and Ameliorate Hypercoagulatory States Associated with Hypercholesterolemia
Authors
Kim, Soo-JinPark, Sin-HeeLee, Hye-WonSchini-Kerth, Valerie B.Kwon, OranLee, Ki WonOak, Min-Ho
Ewha Authors
권오란
SCOPUS Author ID
권오란scopus
Issue Date
2017
Journal Title
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
ISSN
1533-4880JCR Link1533-4899JCR Link
Citation
vol. 17, no. 4, pp. 2817 - 2823
Keywords
Cacao polyphenolsPlatelet AggregationNitric OxideHypercholesterolemiaCardiovascular Diseases
Publisher
AMER SCIENTIFIC PUBLISHERS
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
Platelets are related to the formation of blood clots that play a crucial role in thrombosis and other cardiovascular diseases. Cocoa, derived from Theobroma cocoa, has been widely used as functional food for improving cardiovascular health. In the present study, the direct and indirect effects of cacao polyphenols (CPs) were investigated on human platelet aggregation associated with endothelial cells (ECs) senescence. In addition, the effect of CPs on high-fat diet-(HFD-) induced hypercoagulatory states in rats was evaluated. CPs directly inhibited the human platelet aggregation induced by thromboxane analogue, U46619, and treatment of CPs on senescent endothelial cells markedly restored inhibitory effect of ECs on platelet aggregation. Nitric oxide (NO) from ECs is known as modulator of platelet aggregation and CPs increased eNOS activity in ECs and coronary artery. In animal model, increased TG level induced by high fat diet (HFD) was significantly decreased by CPs administration. In addition, the HFD animal had shorter bleeding time, and CPs administration attenuated the HFD-induced changes. Taken together, the present study indicates that CPs have potent anti-platelet effects most likely by direct and indirect effect via ECs and have the potential for lowering the risk of cardiovascular disease-related hypercoagulation due to hypercholesterolemia.
DOI
10.1166/jnn.2017.13317
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신산업융합대학 > 식품영양학과 > Journal papers
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