Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오세관 | * |
dc.contributor.author | 임예현 | * |
dc.date.accessioned | 2017-04-25T01:04:26Z | - |
dc.date.available | 2017-04-25T01:04:26Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 0006-291X | * |
dc.identifier.other | OAK-20432 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/235007 | - |
dc.description.abstract | Chronic stress is a precipitating factor for disorders including depression. The basolateral amygdala (BLA) is a critical substrate that interconnects with stress-modulated neural networks to generate emotion- and mood-related behaviors. The current study shows that 3 h per day of restraint stress for 14 days caused mice to exhibit long-term depressive behaviors, manifested by disrupted sociality and despair levels, which were rescued by fluoxetine. These behavioral changes corresponded with morphological and molecular changes in BLA neurons, including chronic stress-elicited increases in arborization, dendritic length, and spine density of BLA principal neurons. At the molecular level, calcium-permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (CP-AMPARs) within the synaptosome exhibited an increased GluR1:GluR2 subunit ratio. We also observed increased GluR1 phosphorylation at Ser 845 and enhanced cyclic AMP-dependent protein kinase (PKA) activity in the BLA. These molecular changes reverted to the basal state post-treatment with fluoxetine. The expression of synaptophysin (SYP) and postsynaptic density protein 95 (PSD-95) at BLA neuronal synapses was also enhanced by chronic stress, which was reversed post-treatment. Finally, chronic stress-provoked depressive behavior was overcome by local blockage of CP-AMPARs in the BLA via stereotaxic injection (IEM-1460). Chronic stress-elicited depressive behavior may be due to hypertrophy of BLA neuronal dendrites and increased of PKA-dependent CP-AMPAR levels in BLA neurons. Furthermore, fluoxetine can reverse chronic stress-triggered cytoarchitectural and functional changes of BLA neurons. These findings provide insights into depression-linked structural and functional changes in BLA neurons. © 2017 Elsevier Inc. | * |
dc.language | English | * |
dc.publisher | Elsevier B.V. | * |
dc.subject | BLA | * |
dc.subject | Chronic restraint stress | * |
dc.subject | CP-AMPAR | * |
dc.subject | Dendritic remodeling | * |
dc.subject | Depression | * |
dc.subject | PKA | * |
dc.title | Chronic stress-induced dendritic reorganization and abundance of synaptosomal PKA-dependent CP-AMPA receptor in the basolateral amygdala in a mouse model of depression | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 486 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 671 | * |
dc.relation.lastpage | 678 | * |
dc.relation.journaltitle | Biochemical and Biophysical Research Communications | * |
dc.identifier.doi | 10.1016/j.bbrc.2017.03.093 | * |
dc.identifier.wosid | WOS:000399966700012 | * |
dc.identifier.scopusid | 2-s2.0-85016482478 | * |
dc.author.google | Yi E.-S. | * |
dc.author.google | Oh S. | * |
dc.author.google | Lee J.-K. | * |
dc.author.google | Leem Y.-H. | * |
dc.contributor.scopusid | 오세관(7404103757) | * |
dc.contributor.scopusid | 임예현(25422269100) | * |
dc.date.modifydate | 20240222143226 | * |