View : 856 Download: 0

Full metadata record

DC Field Value Language
dc.contributor.author서주영*
dc.contributor.author오억수*
dc.contributor.author김성은*
dc.contributor.author문창모*
dc.contributor.author정희성*
dc.date.accessioned2017-04-25T01:04:22Z-
dc.date.available2017-04-25T01:04:22Z-
dc.date.issued2017*
dc.identifier.issn0892-6638*
dc.identifier.issn1530-6860*
dc.identifier.otherOAK-20447*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/234994-
dc.description.abstractChronic inflammation is known to be a key causative factor in tumor progression, but we do not yet fully understand the molecular mechanism through which inflammation leads to cancer. Here, we report that the dextran sulfate sodium (DSS)-induced mouse model of chronic colitis is associated with increases in the serum level of IL-1 beta and the colonic epithelial expression of the cell-surface heparan sulfate proteoglycan, syndecan-2. We further show that IL-1b stimulated the transcription of syndecan-2 via NF-kappa B-dependent FOXO3a activation in CCD841CoN normal colonic epithelial cells and early-stage HT29 colon cancer cells. Inflammatory hypoxia was observed in the colonic epithelia of mice with chronic colitis, suggesting that hypoxic stress is involved in the regulation of syndecan-2 expression. Consistently, experimental inflammatory hypoxia induced hypoxia inducible factor-1 alpha-dependent FOXO3a expression and the p38 MAPK-mediated nuclear localization of FOXO3a. FOXO3a directly mediated syndecan-2 expression in both cell lines and the colonic epithelia of mice with DSS-induced colitis. Moreover, syndecan-2 expression was detected in azoxymethane/ DSS-induced colon tumors. Together, these data demonstrate that inflammatory hypoxia upregulates syndecan-2 via the IL-1 beta-NF-kappa B-FOXO3a pathway. These findings provide new mechanistic insights into inflammatory hypoxia-mediated syndecan-2 expression to connect chronic inflammation and the development of colon cancer.-Choi, S., Chung, H., Hong, H., Kim, S. Y., Kim, S.-E., Seoh, J.-Y., Moon, C. M., Yang, E. G., Oh, E.-S. Inflammatory hypoxia induces syndecan-2 expression through IL-1b-mediated FOXO3a activation in colonic epithelia. FASEB J. 31, 1516-1530 (2017). www.fasebj.org*
dc.languageEnglish*
dc.publisherFEDERATION AMER SOC EXP BIOL*
dc.subjectcolon cancer*
dc.subjectFOXO3a*
dc.subjectIL-1 beta*
dc.titleInflammatory hypoxia induces syndecan-2 expression through IL-1 beta-mediated FOXO3a activation in colonic epithelia*
dc.typeArticle*
dc.relation.issue4*
dc.relation.volume31*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.startpage1516*
dc.relation.lastpage1530*
dc.relation.journaltitleFASEB JOURNAL*
dc.identifier.doi10.1096/fj.201601098R*
dc.identifier.wosidWOS:000398504300020*
dc.identifier.scopusid2-s2.0-85017306363*
dc.author.googleChoi, Sojoong*
dc.author.googleChung, Heesung*
dc.author.googleHong, Heejeong*
dc.author.googleKim, So Yeon*
dc.author.googleKim, Seong-Eun*
dc.author.googleSeoh, Ju-Young*
dc.author.googleMoon, Chang Mo*
dc.author.googleYang, Eun Gyeong*
dc.author.googleOh, Eok-Soo*
dc.contributor.scopusid서주영(6603709174;57209001625)*
dc.contributor.scopusid오억수(7101967153)*
dc.contributor.scopusid김성은(35210756100;57204243828;58400567700)*
dc.contributor.scopusid문창모(8131765500)*
dc.contributor.scopusid정희성(35106799300)*
dc.date.modifydate20240222123305*
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

BROWSE