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Impact of Vancomycin MIC on Treatment Outcomes in Invasive Staphylococcus aureus Infections

Title
Impact of Vancomycin MIC on Treatment Outcomes in Invasive Staphylococcus aureus Infections
Authors
Song, Kyoung-HoKim, MoonsukKim, Chung JongCho, Jeong EunChoi, Yun JungPark, Jeong SuAhn, SoyeonJang, Hee-ChangPark, Kyung-HwaJung, Sook-InYoon, NaraKim, Dong-MinHwang, Jeong-HwanLee, Chang SeopLee, Jae HoonKwak, Yee GyungKim, Eu SukPark, Seong YeonPark, YoonseonLee, Kkot SilLee, Yeong-SeonKim, Hong BinKorea INfect Dis Study Grp
Ewha Authors
김충종
SCOPUS Author ID
김충종scopus
Issue Date
2017
Journal Title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN
0066-4804JCR Link1098-6596JCR Link
Citation
vol. 61, no. 3
Keywords
vancomycinStaphylococcus aureusmethicillin resistantmethicillin susceptibleMICbacteremia
Publisher
AMER SOC MICROBIOLOGY
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
There are conflicting data on the association of vancomycin MIC (VAN-MIC) with treatment outcomes in Staphylococcus aureus infections. We investigated the relationship between high VAN-MIC and 30-day mortality and identified the risk factors for mortality in a large cohort of patients with invasive S. aureus (ISA) infections, defined as the isolation of S. aureus from a normally sterile site. Over a 2-year period, 1,027 adult patients with ISA infections were enrolled in 10 hospitals, including 673 (66%) patients with methicillin-resistant S. aureus (MRSA) infections. There were 200 (19.5%) isolates with high VAN-MIC (>= 1.5 mg/liter) by Etest and 87 (8.5%) by broth microdilution (BMD). The all-cause 30-day mortality rate was 27.4%. High VAN-MIC by either method was not associated with all-cause 30-day mortality, and this finding was consistent across MIC methodologies and methicillin susceptibilities. We conclude that high VAN-MIC is not associated with increased risk of all-cause 30day mortality in ISA infections. Our data support the view that VAN-MIC alone is not sufficient evidence to change current clinical practice.
DOI
10.1128/AAC.01845-16
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의료원 > 의료원 > Journal papers
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