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Decreased S100B expression in chronic liver diseases

Title
Decreased S100B expression in chronic liver diseases
Authors
Baik, Su JungKim, Tae HunYoo, KwonMoon, Il HwanChoi, Ju YoungChung, Kyu WonSong, Dong Eun
Ewha Authors
문일환유권김태헌
SCOPUS Author ID
문일환scopus; 유권scopus; 김태헌scopus
Issue Date
2017
Journal Title
KOREAN JOURNAL OF INTERNAL MEDICINE
ISSN
1226-3303JCR Link2005-6648JCR Link
Citation
vol. 32, no. 2, pp. 269 - 276
Keywords
Chronic liver diseaseFibrosisHepatitisNerve fibersS100 proteins
Publisher
KOREAN ASSOC INTERNAL MEDICINE
Indexed
SCIE; KCI WOS
Abstract
Background/Aims: Hepatic innervation in liver diseases is not fully understood. We here evaluated S100B expression as a marker of hepatic nerves in patients with various chronic liver diseases, topographically and semi-quantitatively. Methods: Liver specimens were obtained from 70 subjects (three controls, and 32 chronic hepatitis B, 14 chronic hepatitis C, 14 liver cirrhosis, and seven hepatocellular carcinoma patients). The hepatic nerve density was calculated based on immunohistochemical staining of S100B protein in the portal tracts and hepatic lobules. S100B mRNA levels were semi-quantitatively assessed as the S100B/glyceraldehyde 3-phosphate dehydrogenase (GAPDH) mRNA ratio. Results: The densities of the hepatic nerves in portal tracts of chronic liver diseases were not significantly different from those of normal controls but the hepatic nerve densities in lobular areas of liver cirrhosis were significantly decreased (p = 0.025). Compared to the control, the S100B/GAPDH mRNA ratio was significantly decreased in chronic liver diseases (p = 0.006) and most decreased in chronic hepatitis C patients (p = 0.023). In chronic liver diseases, The S100B/GAPDH mRNA ratio tended to decrease as the fibrosis score > 0 (p = 0.453) but the overall correlation between the S100B/GAPDH mRNA ratio and fibrosis score was not statistically significant (r = 0.061, p = 0.657). Conclusions: Hepatic innervation is decreased in cirrhotic regenerating nodules compared to the control group and seems to decrease in early stages of fibrosis progression. Further studies are needed to clarify the association between changes of hepatic innervation and chronic liver disease progression.
DOI
10.3904/kjim.2015.296
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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