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Efficacy of Levofloxacin-Based Third-Line Therapy for the Eradication of Helicobacter pylori in Peptic Ulcer Disease

Title
Efficacy of Levofloxacin-Based Third-Line Therapy for the Eradication of Helicobacter pylori in Peptic Ulcer Disease
Authors
Lim, Joo HyunKim, Sang GyunSong, Ji HyunHwang, Jae JinLee, Dong HoHan, Jae PilHong, Su JinKim, Ji HyunJeon, Seong WooKim, Gwang HaShim, Ki-NamShin, Woon GeonKim, Tae HoKim, Sun MoonChung, Ii-KwonKim, Hyun-SooKim, Heung UpLee, JoongyubKim, Jae Gyu
Ewha Authors
심기남
SCOPUS Author ID
심기남scopus
Issue Date
2017
Journal Title
GUT AND LIVER
ISSN
1976-2283JCR Link2005-1212JCR Link
Citation
vol. 11, no. 2, pp. 226 - 231
Keywords
LevofloxacinHelicobacter pyloriThird-line eradication
Publisher
EDITORIAL OFFICE GUT & LIVER
Indexed
SCIE; SCOPUS; KCI WOS
Abstract
Background/Aims: The resistance rate of Helicobacter pylori is gradually increasing. We aimed to evaluate the efficacy of levofloxacin-based third-line H. pylori eradication in peptic ulcer disease. Methods: Between 2002 and 2014, 110 patients in 14 medical centers received levofloxacinbased third-line H. pylori eradication therapy for peptic ulcer disease. Of these, 88 were included in the study; 21 were excluded because of lack of follow-up and one was excluded for poor compliance. Their eradication rates, treatment regimens and durations, and types of peptic ulcers were analyzed. Results: The overall eradiation rate was 71.6%. The adherence rate was 80.0%. All except one received a proton pump inhibitor, amoxicillin, and levofloxacin. One received a proton-pump inhibitor, amoxicillin, levofloxacin, and clarithromycin, and the eradication was successful. Thirty-one were administered the therapy for 7 days, 25 for 10 days, and 32 for 14 days. No significant differences were observed in the eradication rates between the three groups (7-days, 80.6% vs 10-days, 64.0% vs 14-days, 68.8%, p=0.353). Additionally, no differences were found in the eradiation rates according to the type of peptic ulcer (gastric ulcer, 73.2% vs duodenal/gastroduodenal ulcer, 68.8%, p=0.655). Conclusions: Levofloxacin-based third-line H. pylori eradication showed ef-ficacy similar to that of previously reported first/second-line therapies.
DOI
10.5009/gnl16099
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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