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Urinary bisphenol A is associated with insulin resistance and obesity in reproductive-aged women

Title
Urinary bisphenol A is associated with insulin resistance and obesity in reproductive-aged women
Authors
Hong, So-hyeonSung, Yeon-AhHong, Young SunHa, EunheeJeong, KyungahChung, HyewonLee, Hyejin
Ewha Authors
하은희성연아정혜원홍영선정경아이혜진홍소현
SCOPUS Author ID
하은희scopus; 성연아scopus; 정혜원scopus; 홍영선scopus; 정경아scopus; 이혜진scopus; 홍소현scopus
Issue Date
2017
Journal Title
CLINICAL ENDOCRINOLOGY
ISSN
0300-0664JCR Link1365-2265JCR Link
Citation
vol. 86, no. 4, pp. 506 - 512
Publisher
WILEY
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Background/ObjectivesThe prevalence of obesity has markedly increased and is closely related to insulin resistance. Although lifestyle and genetic predisposition are significant factors influencing the pathophysiology within the body, endocrine-disrupting chemicals (EDCs) are also important triggers of metabolic disturbance. We investigated the relationship between exposure to EDCs and insulin resistance and obesity in healthy, reproductive-aged women. Subjects/MethodsThis cross-sectional analysis included 296 healthy, reproductive-aged women between 30 and 49 years. Metabolically healthy was defined as an absence of the components of metabolic syndrome. Urinary levels of bisphenol A (BPA), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) and mono-n-butyl phthalate (MnBP) were measured by high-performance liquid chromatography and tandem mass spectroscopy (LC-MS). Homoeostatic model analysis of insulin resistance (HOMA-IR) was utilized as an index of insulin resistance. ResultsUrinary BPA levels were positively correlated with BMI, waist circumference, fasting serum insulin and HOMA-IR. MEHHP, MEOHP and MnBP were not associated with any of the above parameters. In the multiple regression analysis, the BPA levels were significantly associated with BMI and waist circumference after adjusting for age, smoking and alcohol consumption status, triglycerides (TG), total cholesterol (TC) and high-density lipoprotein (HDL). Fasting insulin and HOMA-IR values were also significantly related to urinary BPA concentration after adjusting for confounding variables. Metabolically unhealthy women exhibited significantly higher levels of urinary BPA (P = 001) compared to metabolically healthy women. ConclusionsHigher urinary BPA levels are associated with obesity, insulin resistance and metabolic disruption in Korean reproductive-aged women. BPA could play an important role in the pathogenesis of metabolic abnormalities. Further studies are required to elucidate the relationship between EDCs and metabolic disturbances in various age and sex groups.
DOI
10.1111/cen.13270
Appears in Collections:
의과대학 > 의학과 > Journal papers
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