Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이지희 | * |
dc.contributor.author | 김희선 | * |
dc.contributor.author | 박진선 | * |
dc.date.accessioned | 2017-04-07T01:04:06Z | - |
dc.date.available | 2017-04-07T01:04:06Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 1043-6618 | * |
dc.identifier.other | OAK-20357 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/234915 | - |
dc.description.abstract | Neuroinflammation plays an important role in the progression of various neurodegenerative diseases. In this study, we investigated the anti-inflammatory effects of lonchocarpine, a natural compound isolated from Abrus precatorius, under in vitro and in vivo neuroinflammatory conditions induced by challenge with lipopolysaccharide (LPS)- or polyinosinic-polycytidylic acid (poly(I:C)). Lonchocarpine suppressed the expression of iNOS and proinflammatory cytokines in LPS or poly(I:C)-stimulated BV2 microglial cells. These anti-inflammatory effects were verified in brains of mice with systemic inflammation induced by administration of LPS or poly(I:C). Lonchocarpine reduced the number of Iba-1-positive activated microglia, and suppressed the mRNA expression of various proinflammatory markers in the cortex of LPS- or poly(I:C)-injected mice. Molecular mechanistic experiments showed that lonchocarpine inhibited NF-kappa B activity by reducing the phosphorylation and degradation of I kappa B alpha in LPS- or poly(I:C)-stimulated BV2 cells. Analysis of further upstream signaling pathways in LPS-stimulated microglia showed that lonchocarpine inhibited the phosphorylation of I kappa B kinase and TGF beta-activated kinase 1 (TAK1). Moreover, lonchocarpine suppressed the interaction of myeloid differentiation factor 88 (MyD88) and intereleukin-1 receptor-associated kinase 4 (IRAK4). These data suggest that toll-like receptor 4 downstream signals such as MyD88/IRAK4-TAK1-NF-kappa B are at least partly involved in the anti-inflammatory mechanism of lonchocarpine in LPS-stimulated microglia. Its strong anti-inflammatory effects may make lonchocarpine an effective preventative drug for neuroinflammatory disorders that are associated with systemic inflammation. (C) 2017 Elsevier Ltd. All rights reserved. | * |
dc.language | English | * |
dc.publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | * |
dc.subject | Lonchocarpine | * |
dc.subject | Microglia | * |
dc.subject | Neuroinflammation | * |
dc.subject | Lipopolysaccharide | * |
dc.subject | Poly(I:C) | * |
dc.subject | Molecular mechanism | * |
dc.title | Anti-inflammatory mechanism of lonchocarpine in LPS- or poly(I:C)-induced neuroinflammation | * |
dc.type | Article | * |
dc.relation.volume | 119 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 431 | * |
dc.relation.lastpage | 442 | * |
dc.relation.journaltitle | PHARMACOLOGICAL RESEARCH | * |
dc.identifier.doi | 10.1016/j.phrs.2017.02.027 | * |
dc.identifier.wosid | WOS:000401201600043 | * |
dc.identifier.scopusid | 2-s2.0-85015368982 | * |
dc.author.google | Jeong, Yeon-Hui | * |
dc.author.google | Park, Jin-Sun | * |
dc.author.google | Kim, Dong-Hyun | * |
dc.author.google | Kang, Jihee Lee | * |
dc.author.google | Kim, Hee-Sun | * |
dc.contributor.scopusid | 이지희(7404517577) | * |
dc.contributor.scopusid | 김희선(57191372551) | * |
dc.contributor.scopusid | 박진선(54914743600) | * |
dc.date.modifydate | 20240215165648 | * |