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Delta neutrophil index is an independent predictor of mortality in septic acute kidney injury patients treated with continuous renal replacement therapy

Title
Delta neutrophil index is an independent predictor of mortality in septic acute kidney injury patients treated with continuous renal replacement therapy
Authors
Han, In MiYoon, Chang-YunShin, Dong HoKee, Youn KyungHan, Seung GyuKwon, Young EunPark, Kyoung SookLee, Mi JungOh, Hyung JungPark, Jung TakHan, Seung HyeokKang, Shin-WookYoo, Tae-Hyun
Ewha Authors
오형중
SCOPUS Author ID
오형중scopus
Issue Date
2017
Journal Title
BMC NEPHROLOGY
ISSN
1471-2369JCR Link
Citation
vol. 18
Keywords
Delta neutrophil indexSeptic acute kidney injuryContinuous renal replacement therapyMortality
Publisher
BIOMED CENTRAL LTD
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Background: Delta neutrophil index (DNI), representing an elevated fraction of circulating immature granulocytes in acute infection, has been reported as a useful marker for predicting mortality in patients with sepsis. The aim of this study was to evaluate the prognostic value of DNI in predicting mortality in septic acute kidney injury (S-AKI) patients treated with continuous renal replacement therapy (CRRT). Method: This is a retrospective analysis of consecutively CRRT treated patients. We enrolled 286 S-AKI patients who underwent CRRT and divided them into three groups based on the tertiles of DNI at CRRT initiation (high, DNI > 12. 0%; intermediate, 3.6-12.0%; low, < 3.6%). Patient survival was estimated with the Kaplan-Meier method and Cox proportional hazards models to determine the effect of DNI on the mortality of S-AKI patients. Results: Patients in the highest tertile of DNI showed higher Acute Physiology and Chronic Health Evaluation II score (highest tertile, 27.9 +/- 7.0; lowest tertile, 24.6 +/- 8.3; P = 0.003) and Sequential Organ Failure Assessment score (highest tertile, 14.1 +/- 3.0; lowest tertile, 12.1 +/- 4.0; P = 0.001). The 28-day mortality rate was significantly higher in the highest tertile group than in the lower two tertile groups (P < 0.001). In the multiple Cox proportional hazard model, DNI was an independent predictor for mortality after adjusting multiple confounding factors (hazard ratio, 1.010; 95% confidence interval, 1.001-1.019; P = 0.036). Conclusion: This study suggests that DNI is independently associated with mortality of S-AKI patients on CRRT.
DOI
10.1186/s12882-017-0507-8
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의료원 > 의료원 > Journal papers
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