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Prognostic Role of the MicroRNA-200 Family in Various Carcinomas: A Systematic Review and Meta-Analysis

Title
Prognostic Role of the MicroRNA-200 Family in Various Carcinomas: A Systematic Review and Meta-Analysis
Authors
Lee, Jung SooAhn, Young-HoWon, Hye SungSun, Der ShengKim, Yeo HyungKo, Yoon Ho
Ewha Authors
안영호
SCOPUS Author ID
안영호scopus
Issue Date
2017
Journal Title
BIOMED RESEARCH INTERNATIONAL
ISSN
2314-6133JCR Link2314-6141JCR Link
Publisher
HINDAWI LTD
Indexed
SCIE; SCOPUS WOS
Abstract
Background/Aims. The miRNA-200 (miR-200) family may act as key inhibitors of epithelial-to-mesenchymal transition. However, the potential prognostic value of miR-200s in various human malignancies remains controversial. This meta-analysis analyzed the associations between miR-200 levels and survival outcomes in a variety of tumors. Methods. Eligible published studies were identified by searching theEmbase, PubMed, CINAHL, andGoogle scholar databases. Patient clinical data were pooled, and pooled hazard ratios (HRs) with 95% confidence intervals (95% CI) were used to calculate the strength of this association. Results. The pooled HRs suggested that high tissue expression of miR-200 family members was associated with better survival (overall survival [ OS]: HR = 0.70, 95% CI 0.54-0.91; progression-free survival [ PFS]: HR = 0.63, 95% CI 0.52-0.76) in thirty-four eligible articles. In contrast, higher expression of circulating miR-200 members was significantly associated with poor clinical outcome (OS, HR = 1.68, 95% CI 1.15-2.46; PFS, HR = 2.62, 95% CI 1.68-4.07). Conclusion. The results from this meta-analysis suggest that miR-200 family members are potential prognostic biomarkers in patients with various carcinomas. To apply these findings in the clinic, large prospective studies are needed to validate the prognostic values of miR-200s in individual cancer types.
DOI
10.1155/2017/1928021
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의학전문대학원 > 의학과 > Journal papers
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