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Severe glyphosate-surfactant intoxication: successful treatment with continuous renal replacement therapy
- Severe glyphosate-surfactant intoxication: successful treatment with continuous renal replacement therapy
- Lee, D. H.; Choi, Y. H.
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- HONG KONG JOURNAL OF EMERGENCY MEDICINE
- vol. 24, no. 1, pp. 40 - 44
- Glycine; herbicide; human; multiple organ failure; poisoning
- MEDCOM LTD
- SCIE; SCOPUS
- Glyphosate-surfactant is one of the most commonly used herbicides in the world. Its key component, glyphosate, is a competitive inhibitor of the shikimate pathway, a metabolic pathway found only in plants. However, severe intoxication, including lethal cases by ingestion of, glyphosate-surfactant has been reported. We describe the full recovery of two patients from glyphosate-polyoxyethyleneamine surfactant intoxication and multi-organ system failure following continuous renal replacement therapy. Both patients developed persistent shock, acute kidney injury, lactic acidosis, hyperkalaemia and multi-organ failure despite of resuscitation. We believe that continuous renal replacement therapy should be initiated immediately for removal of glyphosate-polyoxyethyleneamine surfactant in patients with signs of cardiopulmonary compromise, lactic acidosis, and renal failure. We propose the addition of glyphosate-polyoxyethyleneamine surfactant to the list of toxins for which early haemodialysis should be indicated.
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