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Severe glyphosate-surfactant intoxication: successful treatment with continuous renal replacement therapy

Title
Severe glyphosate-surfactant intoxication: successful treatment with continuous renal replacement therapy
Authors
Lee, D. H.Choi, Y. H.
Ewha Authors
최윤희
SCOPUS Author ID
최윤희scopus
Issue Date
2017
Journal Title
HONG KONG JOURNAL OF EMERGENCY MEDICINE
ISSN
1024-9079JCR Link
Citation
vol. 24, no. 1, pp. 40 - 44
Keywords
Glycineherbicidehumanmultiple organ failurepoisoning
Publisher
MEDCOM LTD
Indexed
SCIE; SCOPUS WOS
Abstract
Glyphosate-surfactant is one of the most commonly used herbicides in the world. Its key component, glyphosate, is a competitive inhibitor of the shikimate pathway, a metabolic pathway found only in plants. However, severe intoxication, including lethal cases by ingestion of, glyphosate-surfactant has been reported. We describe the full recovery of two patients from glyphosate-polyoxyethyleneamine surfactant intoxication and multi-organ system failure following continuous renal replacement therapy. Both patients developed persistent shock, acute kidney injury, lactic acidosis, hyperkalaemia and multi-organ failure despite of resuscitation. We believe that continuous renal replacement therapy should be initiated immediately for removal of glyphosate-polyoxyethyleneamine surfactant in patients with signs of cardiopulmonary compromise, lactic acidosis, and renal failure. We propose the addition of glyphosate-polyoxyethyleneamine surfactant to the list of toxins for which early haemodialysis should be indicated.
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의과대학 > 의학과 > Journal papers
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