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Recent epidemiology of Streptococcus pneumoniae in nasopharynxes of Korean children with acute otitis media

Title
Recent epidemiology of Streptococcus pneumoniae in nasopharynxes of Korean children with acute otitis media
Authors
Han, Seung BeomKim, Jong-HyunKang, Jin HanMa, Sang HyukKim, Chun SooKim, Kyung-HyoKim, Hwang MinChoi, Young Youn
Ewha Authors
김경효
SCOPUS Author ID
김경효scopus
Issue Date
2017
Journal Title
JOURNAL OF INFECTION AND CHEMOTHERAPY
ISSN
1341-321XJCR Link1437-7780JCR Link
Citation
vol. 23, no. 3, pp. 136 - 141
Keywords
Acute otitis mediaStreptococcus pneumoniaeChildKorea
Publisher
ELSEVIER SCIENCE BV
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Background: This prospective study was performed to evaluate serotype distribution, multilocus sequence typing, and antibiotic susceptibility of Streptococcus pneumoniae identified in Korean children with acute otitis media (AOM) after the introduction of a 7-valent pneumococcal conjugate vaccine (PCV7). Methods: Nasopharyngeal aspirates were collected from children diagnosed with AOM in seven hospitals in Korea. The bacteria identified in these samples and the serotypes, sequence types (STs), and antibiotic susceptibilities of S. pneumoniae isolates were evaluated. Results: A total of 390 children were enrolled, and bacteria were identified in 376 (96.4%) children. S. pneumoniae, Haemophilus influenzae and Moraxella catarrhalis were identified in 155 (39.7%), 127 (32.6%) and 86 (22.1%) children, respectively. Serotype 19A (22.4%) was the most common S. pneumoniae serotype, with serogroups 11 (14.7%) and 15 (13.5%) following. ST320 (23.5%) was the most common ST; ST166 (17.0%) and ST83 (8.5%) followed. The overall susceptibility rates of S. pneumoniae to oral penicillin V and amoxicillin/clavulanate were 2.6% and 53.2%, respectively. The susceptibility rate to cefditoren was 91.0%; however, the rates for other cephalosporins were less than 10.0%. Compared with other serogroups, S. pneumoniae serogroups 19, 11, and 15 showed significantly lower susceptibility rates to all the antibiotics tested. Conclusion: S. pneumoniae serotype 19A, serogroups 11 and 15 were the major nasopharyngeal-colonizing bacteria in Korean children with AOM after the introduction of PCV7. These relatively prevalent serotype/serogroups showed lower antibiotic susceptibility rates. (C) 2016 Published by Elsevier Ltd on behalf of Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.
DOI
10.1016/j.jiac.2016.10.006
Appears in Collections:
의과대학 > 의학과 > Journal papers
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