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Multiple cavitating pulmonary nodules: rare manifestation of benign metastatic leiomyoma

Title
Multiple cavitating pulmonary nodules: rare manifestation of benign metastatic leiomyoma
Authors
Lee, Sa RaChoi, Youn-ILee, Seok JeongShim, Sung ShineLee, Jin HwaKim, Yoo KyungSung, Soon Hee
Ewha Authors
성순희김유경이진화심성신이사라이석정
SCOPUS Author ID
성순희scopus; 김유경scopus; 이진화scopus; 심성신scopus; 이사라scopus
Issue Date
2017
Journal Title
JOURNAL OF THORACIC DISEASE
ISSN
2072-1439JCR Link2077-6624JCR Link
Citation
vol. 9, no. 1, pp. E1 - E5
Keywords
Leiomyomacavitylunggonadotrophin releasing hormone agonist (GnRH agonist)
Publisher
PIONEER BIOSCIENCE PUBL CO
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Benign metastasizing leiomyoma (BML) is a rare disease of pathologically benign, but the tumor metastasizes to other organs. The most common organ involved in BML is lung. Pulmonary involvement usually manifested as multiple nodules on chest X-ray, however we experienced an interesting case of a 52-year-old premenopausal woman who presented with multiple bilateral lung cavitations and nodules on a chest X-ray without any respiratory symptoms. Chest computed-tomography identified multiple cavitary lesions of 5-12 mm in diameter and well-defined nodules of 5-10 mm in diameter in both lung fields. Transthoracic needle biopsy was performed and the resected lesion consisted of benign spindle cells was positive for estrogen receptor (ER) and progesterone receptor (PR) and was diffuse positive for actin and desmin by immunohistochemical (IHC) staining, suggesting leiomyoma. The final diagnosis was benign pulmonary metastasizing leiomyoma (BPML) and the patient underwent subcutaneous injection of a gonadotrophin releasing hormone (GnRH) agonist for 12 months, follow-up low-dose chest computed tomography (CT) scan at 15 months revealed decreased cavitations and nodular lesions. We should take into consideration the possibility of BPML when we encounter multiple cystic or cavitary lesions on chest X-ray, although the common form of BPML is nodulary lesions on imaging studies.
DOI
10.21037/jtd.2016.11.112
Appears in Collections:
의과대학 > 의학과 > Journal papers
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