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Cerebral white matter abnormalities in patients with charcot-marie-tooth disease

Title
Cerebral white matter abnormalities in patients with charcot-marie-tooth disease
Authors
Lee, MinaPark, Chang-hyunChung, Hwa-KyungKim, Hyeon JinChoi, YunseoYoo, Jeong HyunYoon, Young ChulHong, Young BinChung, Ki WhaChoi, Byung-OkLee, Hyang Woon
Ewha Authors
유정현최병옥이향운홍영빈박창현
SCOPUS Author ID
유정현scopus; 이향운scopus; 박창현scopus
Issue Date
2017
Journal Title
ANNALS OF NEUROLOGY
ISSN
0364-5134JCR Link1531-8249JCR Link
Citation
vol. 81, no. 1, pp. 147 - 151
Publisher
WILEY-BLACKWELL
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Here, we report the structural evidence of cerebral white matter abnormalities in Charcot-Marie-Tooth (CMT) patients and the relationship between these abnormalities and clinical disability. Brain diffusion tensor imaging (DTI) was performed in CMT patients with demyelinating (CMT1A/CMT1E), axonal (CMT2A/CMT2E), or intermediate (CMTX1/DI-CMT) peripheral neuropathy. Although all patients had normal brain magnetic resonance imaging, all genetic subgroups except CMT1A had abnormal DTI findings indicative of significant cerebral white matter abnormalities: decreased fractional anisotropy and axial diffusivity, and increased radial diffusivity. DTI abnormalities were correlated with clinical disability, suggesting that there is comorbidity of central nervous system damage with peripheral neuropathy in CMT patients. ANN NEUROL 2017;81:147-151
DOI
10.1002/ana.24824
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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