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Two-photon fluorescence sensors for imaging NMDA receptors and monitoring release of Zn2+ from the presynaptic terminal
- Two-photon fluorescence sensors for imaging NMDA receptors and monitoring release of Zn2+ from the presynaptic terminal
- Chen X.; Lim C.S.; Lee D.; Lee S.; Park S.J.; Kim H.M.; Yoon J.
- Ewha Authors
- 윤주영; Chen Xiaoqiang
- SCOPUS Author ID
- Issue Date
- Journal Title
- Biosensors and Bioelectronics
- vol. 91, pp. 770 - 779
- Fluorescent probes; NMDA receptors; Presynaptic terminal; Two-photon imaging; Zinc ions
- Elsevier Ltd
- SCI; SCIE; SCOPUS
- Synaptic Zn2+ plays an important role in neurotransmission and a neuromodulator. The development of the imaging tools for monitoring spatiotemporal changes taking place in synaptic Zn2+ concentrations is necessary in order to understand the role of Zn2+ in the function of many aspects of the glutamate system. In this work, two-photon probes 1 and 2, bearing ifenprodil-like tails that have affinity for NMDA receptors of neuronal cells, were designed and prepared. The two-photon fluorescent probe 1, which bears (N-(6-acetylnaphthalen-2-yl)-N-methylglycine) as two-photon fluorophore, enables high resolution imaging of neuronal cells. The two-photon fluorescent probe 2, which contains the di-2-picolylamine (DPA) as a Zn2+-binding site, the naphthalimide unit as the two-photon fluorophore, and the ifenprodil-like tail as the NMDA receptor binding moiety, can be employed for selective detection of Zn2+ located near the NMDA receptor and for monitoring concentration changes of Zn2+ in live neurons and hippocampal tissues. © 2017 Elsevier B.V.
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