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Therapeutic Antibodies by Phage Display

Title
Therapeutic Antibodies by Phage Display
Authors
Shim, Hyunbo
Ewha Authors
심현보
SCOPUS Author ID
심현보scopus
Issue Date
2016
Journal Title
CURRENT PHARMACEUTICAL DESIGN
ISSN
1381-6128JCR Link1873-4286JCR Link
Citation
vol. 22, no. 43, pp. 6538 - 6559
Keywords
Phage displayantibodiestherapeutic antibodiesfully human antibodiesantibody librariesnatural antibody librariessynthetic antibody librariessemi-synthetic antibody libraries
Publisher
BENTHAM SCIENCE PUBL LTD
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Background: Antibody phage display is a major technological platform for the generation of fully human antibodies for therapeutic purposes. The in vitro binder selection by phage display allows researchers to have more extensive control over binding parameters and facilitates the isolation of clinical candidate antibodies with desired binding and/or functional profiles. Methods: Since the invention of antibody phage display in late 1980s, significant technological advancements in the design, construction, and selection of the antibody libraries have been made, and several fully human antibodies generated by phage display are currently approved or in various clinical development stages. Results: In this review, the background and details of antibody phage display technology, and representative antibody libraries with natural or synthetic sequence diversity and different construction strategies are described. The generation, optimization, functional and biophysical properties, and preclinical and clinical developments of some of the phage display-derived therapeutic antibodies approved for use in patients or in late-stage clinical trials are also discussed. Conclusion: With evolving novel disease targets and therapeutic strategies, antibody phage display is expected to continue to play a central role in the development of the next generation of therapeutic antibodies.
DOI
10.2174/1381612822666160923113714
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일반대학원 > 바이오융합과학과 > Journal papers
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