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Pharmacological intervention of early neuropathy in neurodegenerative diseases

Title
Pharmacological intervention of early neuropathy in neurodegenerative diseases
Authors
Kwon, Min JeeKim, Jeong-HoonKim, TaeSooLee, Sung Bae
Ewha Authors
김태수
SCOPUS Author ID
김태수scopus
Issue Date
2017
Journal Title
PHARMACOLOGICAL RESEARCH
ISSN
1043-6618JCR Link
Citation
vol. 119, pp. 169 - 177
Keywords
Epigenetic changesEarly neuropathyNeurodegenerative diseaseTranscriptional dysregulation
Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Extensive studies have reported the significant roles of numerous cellular features and processes in properly maintaining neuronal morphology and function throughout the lifespan of an animal. Any alterations in their homeostasis appear to be strongly associated with neuronal aging and the pathogenesis of various neurodegenerative diseases, even before the occurrence of prominent neuronal death. However, until recently, the primary focus of studies regarding many neurodegenerative diseases has been on the massive cell death occurring at the late stages of disease progression. Thus, our understanding on early neuropathy in these diseases remains relatively limited. The complicated nature of various neuropathic features manifested early in neurodegenerative diseases suggests the involvement of a system-wide transcriptional regulation and epigenetic control. Epigenetic alterations and consequent changes in the neuronal transcriptome are now begun to be extensively studied in various neurodegenerative diseases. Upon the catastrophic incident of neuronal death in disease progression, it is utterly difficult to reverse the deleterious defects by pharmacological treatments, and therefore, therapeutics targeting the system-wide transcriptional dysregulation associated with specific early neuropathy is considered a better option. Here, we review our current understanding on the system-wide transcriptional dysregulation that is likely associated with early neuropathy shown in various neurodegenerative diseases and discuss the possible future developments of pharmaceutical therapeutics. (C) 2017 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.phrs.2017.02.003
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자연과학대학 > 생명과학전공 > Journal papers
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