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Relationship between survival and age in patients with idiopathic pulmonary fibrosis

Title
Relationship between survival and age in patients with idiopathic pulmonary fibrosis
Authors
Koo, So-MyUh, Soo-TaekKim, Dong SoonKim, Young WhanChung, Man PyoPark, Choon SikJeong, Sung HwanPark, Yong BumLee, Hong LyeolShin, Jong WookLee, Eun JooLee, Jin HwaJegal, YanginLee, Hyun KyungKim, Yong HyunSong, Jin WooPark, Moo SukHwangbo, Young
Ewha Authors
이진화
SCOPUS Author ID
이진화scopus
Issue Date
2016
Journal Title
JOURNAL OF THORACIC DISEASE
ISSN
2072-1439JCR Link2077-6624JCR Link
Citation
vol. 8, no. 11, pp. 3255 - 3264
Keywords
Idiopathic pulmonary fibrosis (IPF)age factorsprognosissurvival analysisrelative survival
Publisher
PIONEER BIOSCIENCE PUBL CO
Indexed
SCIE; SCOPUS WOS
Abstract
Background: There is a debate that older patients with idiopathic pulmonary fibrosis (IPF) have a worse prognosis. We evaluated whether age affects the survival of patients with IPF. Methods: The Korean Interstitial Lung Disease (ILD) Research Group conducted a national survey to evaluate the clinical, physiological, radiological, and survival characteristics of patients with IPF. A total of 1,663 patients with IPF were stratified into three groups according to age: (I) <60 years (n=309); (II) 60-69 years (n=613); and (III) >= 70 years (n=741). Results: The 1-, 3- and5- year observed survival rates were 83.0%, 62.6%, and 49.2% in the total population, respectively. The 1-, 3-, and 5-year relative survival rates were 85.7%, 69.1%, and 58.0% in all patients, respectively. The observed survival rate of the group >= 70 years of age was significantly lower than those of the other groups (P<0.001). In contrast, no significant difference in relative survival rate was detected among the three age groups. Compared with patients less than 60 years of age, patients with above 70 years of age had not increased risk of worse relative survival [P=0.252; hazard ratio (HR), 1.11; 95% confidence interval (CI), 0.76-1.64]. Conclusions: The prognosis of patients above 70 years of age with IPF was not different to that of patients less than 60 years of age, using relative survival rate. Age may not affect survival in patients with IPF.
DOI
10.21037/jtd.2016.11.40
Appears in Collections:
의과대학 > 의학과 > Journal papers
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