Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤주영 | * |
dc.contributor.author | 김진흥 | * |
dc.date.accessioned | 2017-03-01T01:03:44Z | - |
dc.date.available | 2017-03-01T01:03:44Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 1144-0546 | * |
dc.identifier.issn | 1369-9261 | * |
dc.identifier.other | OAK-20219 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/234627 | - |
dc.description.abstract | Two new dinuclear iridium (Ir) complexes bridged by a conjugated aromatic tppz ligand, (bhq)(2)Ir(tppz)Ir(bhq)(2) (1) and (ppy)(2)Ir(tppz)Ir(ppy)(2) (2) (bhq = benzo(h)quinolone, ppy = phenyl-pyridine, tppz = tetrapyrido[ 3,2-a:2',3'-c:3 '',2 ''-h:2''',3'''-j] phenazine), were prepared. The DNA binding properties of complexes 1 and 2 were studied using single-stranded DNA, double-stranded DNA, and G-quadruplex DNA. G-Quadruplex binding was characterized by higher emission enhancements than those observed with other control DNA strands. Photophysical properties of complexes 1 and 2 indicated that 1 displayed selective G-quadruplex binding affinity, but 2 did not. The emission properties of complexes 1 and 2 were also studied using liposomes in order to understand their possible interactions with lipid-rich organelles in live cells. The phosphorescence intensity of 1 and 2 was enhanced upon interaction with liposomes, but 2 showed greater enhancement. We also confirmed that 1 and 2 could be used as probes in live cells. Complexes 1 and 2 were intensely stained in HeLa cervical cancer cells. Excitation with a lambda = 488 nm laser showed red emission localized in the cytosol of cells. Cellular studies showed that 1 and 2 were located inside HeLa cells, but neither complex passed through the nuclear membrane. However, complexes 1 and 2 possessed superior photostability, indicating their role as good luminescent agents for imaging and tracking the endoplasmic reticulum (ER) in live cells. Overall, complex 1 exhibited better selectivity for G-quadruplexes, liposomes, and ER staining. | * |
dc.language | English | * |
dc.publisher | ROYAL SOC CHEMISTRY | * |
dc.title | Diiridium(III) complexes: luminescent probes and sensors for G-quadruplex DNA and endoplasmic reticulum imaging | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 41 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 377 | * |
dc.relation.lastpage | 386 | * |
dc.relation.journaltitle | NEW JOURNAL OF CHEMISTRY | * |
dc.identifier.doi | 10.1039/c6nj02890j | * |
dc.identifier.wosid | WOS:000391451500043 | * |
dc.author.google | Anjong, Tikum Florence | * |
dc.author.google | Kim, Gyoungmi | * |
dc.author.google | Jang, Ha Yoon | * |
dc.author.google | Yoon, Juyoung | * |
dc.author.google | Kim, Jinheung | * |
dc.contributor.scopusid | 윤주영(7403587371) | * |
dc.contributor.scopusid | 김진흥(8580015800) | * |
dc.date.modifydate | 20240118162450 | * |