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Opioid sparing effect and safety of nefopam in patient controlled analgesia after laparotomy: A randomized, double blind study

Title
Opioid sparing effect and safety of nefopam in patient controlled analgesia after laparotomy: A randomized, double blind study
Authors
Jin, Hyun SeungKim, Yong ChulYoo, YongjaeLee, ChangsoonCho, Chan WooKim, Won-joong
Ewha Authors
김원중
Issue Date
2016
Journal Title
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
ISSN
0300-0605JCR Link1473-2300JCR Link
Citation
vol. 44, no. 4, pp. 844 - 854
Keywords
Adverse eventsnefopamfentanylopioid sparingpatient controlled analgesialaparotomy
Publisher
SAGE PUBLICATIONS LTD
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Objectives A double-blind randomised study to evaluate the opioid sparing effect and safety of nefopam when administered via intravenous patient controlled analgesia (PCA) with fentanyl. Methods Patients planned for elective open laparotomy, were randomly assigned to receive into fentanyl 25 mu g/ml (SF group) or nefopam 2.4mg/ml plus fentanyl 25 mu g/ml (NF group). Patients were assessed before surgery and for 24h postoperatively. Results Total PCA fentanyl consumption was significantly lower in the NF group (n=35) than the SF group (n=36). Pain scores were significantly lower and patients' satisfaction with treatment significantly better in the NF group than the SF group. Dry mouth and dizziness were significantly more frequent in the NF group than the SF group. There were no other statistically significant between-group differences in the incidence of adverse events. Conclusions Intravenous PCA using nefopam+fentanyl following laparotomy has an opioid sparing effect and is associated with a low incidence of some of the typical opioid related adverse events. Trial registry Clinicaltrials.gov Registration No: NCT02596269
DOI
10.1177/0300060516650783
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