Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤주영 | * |
dc.contributor.author | Chen Xiaoqiang | * |
dc.date.accessioned | 2017-02-15T08:02:09Z | - |
dc.date.available | 2017-02-15T08:02:09Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 0142-9612 | * |
dc.identifier.issn | 1878-5905 | * |
dc.identifier.other | OAK-20106 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/234535 | - |
dc.description.abstract | The development of multifunctional reagents for simultaneous specific near-infrared (NIR) imaging and phototherapy of tumors is of great significance. This work describes the design of a cathepsin B-activated fluorescent probe (CyA-P-CyB) and its applications as an NIR imaging probe for tumor cells and as a phototherapy reagent for tumors. In vitro experiments demonstrated that CyA-P-CyB was activated via the cleavage of a peptide linker by cathepsin B in tumor cells to produce fluorescence in the NIR region based on a FRET mechanism. MTT assays showed that the phototoxicity of CyA-P-CyB toward cells depended on the activity of cathepsin B, and the probe exhibited specific phototoxicity toward tumor cells. CyA-P-CyB was also successfully applied to the in vivo imaging and phototherapy of tumors. Histological analysis indicated that CyA-P-CyB had no cytotoxic effects on seven mouse tissues (lung, liver, heart, kidney, pancreas, spleen and brain) after the CyA-P-CyB treatment and laser irradiation. (C) 2017 Elsevier Ltd. All rights reserved. | * |
dc.language | English | * |
dc.publisher | ELSEVIER SCI LTD | * |
dc.subject | Specific phototherapy | * |
dc.subject | NIR bioimaging | * |
dc.subject | Enzyme-activated fluorescence | * |
dc.subject | Multiple functional probe | * |
dc.title | In vivo near-infrared imaging and phototherapy of tumors using a cathepsin B-activated fluorescent probe | * |
dc.type | Article | * |
dc.relation.volume | 122 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 130 | * |
dc.relation.lastpage | 140 | * |
dc.relation.journaltitle | BIOMATERIALS | * |
dc.identifier.doi | 10.1016/j.biomaterials.2017.01.020 | * |
dc.identifier.wosid | WOS:000394472500012 | * |
dc.identifier.scopusid | 2-s2.0-85010210696 | * |
dc.author.google | Chen, Xiaoqiang | * |
dc.author.google | Lee, Dayoung | * |
dc.author.google | Yu, Sungsook | * |
dc.author.google | Kim, Gyoungmi | * |
dc.author.google | Lee, Songyi | * |
dc.author.google | Cho, Yejin | * |
dc.author.google | Jeong, Haengdueng | * |
dc.author.google | Nam, Ki Taek | * |
dc.author.google | Yoon, Juyoung | * |
dc.contributor.scopusid | 윤주영(7403587371) | * |
dc.date.modifydate | 20240118162450 | * |