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Triple therapy versus sequential therapy for the first-line Helicobacter pylori eradication

Title
Triple therapy versus sequential therapy for the first-line Helicobacter pylori eradication
Authors
Chang, Ji YoungShim, Ki-NamTae, Chung HyunLee, Ko EunLee, JihyunLee, Kang HoonMoon, Chang MoKim, Seong-EunJung, Hye-KyungJung, Sung-Ae
Ewha Authors
정성애정혜경심기남김성은문창모태정현
SCOPUS Author ID
정성애scopus; 정혜경scopus; 심기남scopus; 김성은scopus; 문창모scopus; 태정현scopusscopus
Issue Date
2017
Journal Title
BMC GASTROENTEROLOGY
ISSN
1471-230XJCR Link
Citation
vol. 17
Keywords
Helicobacter pyloriAnti-bacterial agentsFirst-line triple therapySequential therapy
Publisher
BIOMED CENTRAL LTD
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Background: The eradication rate of Helicobacter pylori (H. pylori) with triple therapy which was considered as standard first-line treatment has decreased to 70-85%. The aim of this study is to compare 7-day triple therapy versus 10-day sequential therapy as the first line treatment. Methods: Data of 1240 H. pylori positive patients treated with triple therapy or sequential therapy from January 2013 to December 2015 were analyzed retrospectively. The patients who had undertaken previous H. pylori eradication therapy or gastric surgery were excluded. Results: There were 872 (74.3%) patients in the triple therapy group, and 302 (25.7%) patients in the sequential therapy group. There was no significant difference between the two groups regarding age, residence, comorbidities or drug compliance, but several differences were noted in endoscopic characteristics and indication for the treatment. The eradication rate of H. pylori by intention to treat analysis was 64.3% in the triple therapy group, and 81.9% in the sequential therapy group (P = 0.001). In per protocol analysis, H. pylori eradication rate in the triple therapy and sequential therapy group was 81.9 and 90.3%, respectively (P = 0.002). There was no significant difference in overall adverse events between the two groups (P = 0.706). For the rescue therapy, bismuth-containing quadruple therapy showed comparable treatment efficacy after sequential therapy, as following triple therapy. Conclusions: The eradication rate of triple therapy was below the recommended threshold. Sequential therapy could be effective and tolerable candidate for the first-line H. pylori eradication therapy.
DOI
10.1186/s12876-017-0579-8
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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