View : 238 Download: 0
Comparing the clinical outcomes of young-onset and adult-onset ulcerative colitis: a multi-center Korean Association for the Study for Intestinal Diseases study
- Comparing the clinical outcomes of young-onset and adult-onset ulcerative colitis: a multi-center Korean Association for the Study for Intestinal Diseases study
- Kim, Ji Yeon; Park, Dong Il; Han, Dong Soo; Huh, Kyu-Chan; Lee, Chang Kyun; Shin, Jeong Eun; Kim, Jae Hak; Kim, You Sun; Jung, Yunho; Jung, Sung-Ae; Song, Hyun Joo; Jang, Hyun Joo; Kim, Young-Ho; Hong, Sung No
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- KOREAN JOURNAL OF INTERNAL MEDICINE
- KOREAN JOURNAL OF INTERNAL MEDICINE vol. 32, no. 1, pp. 69 - +
- Colitis, ulcerative; Young-onset; Clinical feature; Outcome
- KOREAN ASSOC INTERNAL MEDICINE
- SCIE; SCOPUS; KCI
- Document Type
- Background/Aims: The aim of this study was to compare the clinical features and outcomes of ulcerative colitis (UC) according to the age of onset in Korea. Methods: A total of 1,141 patients who were diagnosed with UC between July 1987 and November 2013 at 11 tertiary hospitals were enrolled. The baseline disease characteristic and disease state at onset, treatment during the disease course were retrospectively reviewed among patients with young-onset (YO, < 20 years) and adult-onset (AO, >= 20 years). Severe outcome was defined as use of intravenous (IV) steroids, infliximab, immunosuppressant, or UC-related operation. Results: There were 55 YO patients (mean age, 17.8 +/- 2.4) and 1,086 AO patients (mean age, 43.0 +/- 13.6). High Mayo scores (7.7 +/- 3.0 vs. 5.6 +/- 2.7, p = 0.000), extensive UC (52.7% vs. 25.8%, p = 0.000) and IV steroid (41.8% vs. 18.0%, p = 0.000), immunosuppressant (47.3% vs. 26.9%, p = 0.002), and infliximab (20.0% vs. 7.2%, p = 0.001) use were more frequent in the YO than in the AO group. According to multivariate analysis, severe outcomes were related to YO disease (hazard ratio [HR], 2.18; 95% confidence interval [CI], 1.27 to 3.71), body mass index < 23 kg/m(2) (HR, 1.46; 95% CI, 1.07 to 2.00), severe (HR, 2.29; 95% CI, 1.36 to 3.38), and moderate (HR, 2.48; 95% CI, 1.67 to 3.67) disease, extensive UC (HR, 2.90; 95% CI, 1.79 to 4.69), UC-related admission (HR, 63.89; 95% CI, 20.41 to 200.02), and oral steroid use (HR, 0.51; 95% CI, 0.39 to 0.67). Conclusions: UC with YO presented with more advanced clinical features at onset and more severe outcomes than the AO. YO cases require careful management and intense treatment strategies.
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.