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dc.contributor.author이경자-
dc.contributor.author김승철-
dc.contributor.author문혜성-
dc.contributor.author이레나-
dc.contributor.author주웅-
dc.contributor.author김윤환-
dc.contributor.author이지혜-
dc.contributor.author박경란-
dc.date.accessioned2017-08-29T05:36:07Z-
dc.date.available2017-08-29T05:36:07Z-
dc.date.issued2016-
dc.identifier.issn2234-1900-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/234479-
dc.description.abstractPurpose: The purpose of this study is to evaluate the treatment outcomes of adjuvant radiotherapy using vaginal brachytherapy (VB) with a lower dose per fraction and/or external beam radiotherapy (EBRT) following surgery for patients with stage I endometrial carcinoma. Materials and Methods: The subjects were 43 patients with the International Federation of Gynecology and Obstetrics (FIGO) stage I endometrial cancer who underwent adjuvant radiotherapy following surgery between March 2000 and April 2014. Of these, 25 received postoperative VB alone, while 18 received postoperative EBRT to the whole pelvis; 3 of these were treated with EBRT plus VB. The median EBRT dose was 50.0 Gy (45.0-50.4 Gy) and the VB dose was 24 Gy in 6 fractions. Tumor dose was prescribed at a depth of 5 mm from the cylinder surface and delivered twice per week. Results: The median follow-up period for all patients was 57 months (range, 9 to 188 months). Five-year disease-free survival (DFS) and overall survival (OS) for all patients were 92.5% and 95.3%, respectively. Adjuvant radiotherapy was performed according to risk factors and stage IB, grade 3 and lymphovascular invasion were observed more frequently in the EBRT group. Five-year DFS for EBRT and VB alone were 88.1% and 96.0%, respectively (p = 0.42), and 5-year OS for EBRT and VB alone were 94.4% and 96%, respectively (p = 0.38). There was no locoregional recurrence in any patient. Two patients who received EBRT and 1 patient who received VB alone developed distant metastatic disease. Two patients who received EBRT had severe complications, one each of grade 3 gastrointestinal complication and pelvic bone insufficiency fracture. Conclusion: Adjuvant radiotherapy achieved high DFS and OS with acceptable toxicity in stage I endometrial cancer. VB (with a lower dose per fraction) may be a viable option for selected patients with early-stage endometrial cancer following surgery. © 2016. The Korean Society for Radiation Oncology.-
dc.languageEnglish-
dc.publisherDepartment of Radiation Oncology-
dc.subjectAdjuvant radiotherapy-
dc.subjectConformal radiotherapy-
dc.subjectEndometrial cancer-
dc.subjectIntracavity radiotherapy-
dc.titleTreatment outcomes after adjuvant radiotherapy following surgery for patients with stage i endometrial cancer-
dc.typeArticle-
dc.relation.issue4-
dc.relation.volume34-
dc.relation.indexSCOPUS-
dc.relation.startpage265-
dc.relation.lastpage272-
dc.relation.journaltitleRadiation Oncology Journal-
dc.identifier.doi10.3857/roj.2016.01648-
dc.identifier.scopusid2-s2.0-85007578330-
dc.author.googleKim J.-
dc.author.googleLee K.-J.-
dc.author.googlePark K.-R.-
dc.author.googleHa B.-
dc.author.googleKim Y.-J.-
dc.author.googleJung W.-
dc.author.googleLee R.-
dc.author.googleKim S.C.-
dc.author.googleMoon H.S.-
dc.author.googleJu W.-
dc.author.googleKim Y.H.-
dc.author.googleLee J.-
dc.contributor.scopusid이경자(55540780700)-
dc.contributor.scopusid김승철(35264000100)-
dc.contributor.scopusid문혜성(14319143700)-
dc.contributor.scopusid이레나(8694612100)-
dc.contributor.scopusid주웅(8873659700)-
dc.contributor.scopusid김윤환(55763947200)-
dc.contributor.scopusid이지혜(55668091000)-
dc.contributor.scopusid박경란(14040340300)-
dc.date.modifydate20180403152707-
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의과대학 > 의학과 > Journal papers
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