View : 206 Download: 0

Effects of repeated dizocilpine treatment on glutamatergic activity in the prefrontal cortex in an animal model of schizophrenia: An in vivo proton magnetic resonance spectroscopy study at 9.4 T

Title
Effects of repeated dizocilpine treatment on glutamatergic activity in the prefrontal cortex in an animal model of schizophrenia: An in vivo proton magnetic resonance spectroscopy study at 9.4 T
Authors
Yoo, Chi-HyeonSong, Kyu-HoLim, Song-ILee, Do-WanWoo, Dong-CheolChoe, Bo-Young
Ewha Authors
이도완
Issue Date
2017
Journal Title
NEUROSCIENCE LETTERS
ISSN
0304-3940JCR Link1872-7972JCR Link
Citation
vol. 637, pp. 57 - 63
Keywords
Dizocilpine (MK-801)SchizophreniaIn vivo proton magnetic resonance spectroscopy (H-1 MRS)Glutamatergic activity
Publisher
ELSEVIER IRELAND LTD
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Repeated exposure to dizocilpine (MK-801) can be used as a model of schizophrenia that incorporates disease progression. Proton magnetic resonance spectroscopy (H-1 MRS) has been widely used to investigate schizophrenia-related alterations in glutamate (Glu). The purpose of this study was to investigate metabolic alterations in the prefrontal cortex (PFC) in an animal model of schizophrenia by using in vivo H-1 MRS. Because of the spectral overlap of Glu and glutamine (Gin), high-field 1H MRS with short echo time (TE) was used. A point-resolved spectroscopy sequence was used to measure the levels of Glu and Gln, and the brain metabolites in a volume of interest (22.5 pt) located in the PFC region of rats (n=13) before and after 6days of MK-801 (0.5 mg/kg) treatment. Analysis of the spectra showed that the cross-contamination of Glu and Gln can be considered to comparably low. No metabolic parameters were altered (p > 0.05). However, differences in Glu and N-acetylaspartate (NAA) levels between two times were significantly correlated (p < 0.01). The results showed both decreased (in 6 of the 13 rats) and increased (7 of the 13 rats) levels of Glu and NAA, which suggested that these opposite metabolic alterations reflect two stage of disease progression. The results suggest that high-field and short TE in vivo H-1 MRS can quantify Glu and Gln with reliably low level of cross-contamination and that repeated exposure to MK-801 induces the progressive development of schizophrenia. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
DOI
10.1016/j.neulet.2016.11.053
Appears in Collections:
연구기관 > 뇌융합과학연구원 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE