Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김양하 | * |
dc.date.accessioned | 2017-02-15T08:02:55Z | - |
dc.date.available | 2017-02-15T08:02:55Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 1756-4646 | * |
dc.identifier.other | OAK-20038 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/234470 | - |
dc.description.abstract | Mitochondrial dysfunction and dyslipidemia are associated with obesity-linked metabolic disorders. The aim of this study was to investigate the effects of ginger extract on muscle mitochondrial biogenesis and high-density lipoprotein-cholesterol (HDL-C) metabolism in high-fat diet-fed rats. Supplementation with ginger extract reduced final body weight and epididymal adipose tissue mass without affecting energy intake (p < 0.05). Ginger extract increased mitochondrial size and mitochondrial DNA (mtDNA) content as well as key genes expression related to mitochondrial biogenesis, including peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha), nuclear respiratory factor-1 (NRF-1) and transcription factor A (Tfam) in skeletal muscle (p < 0.05). In addition, ginger extract elevated serum HDL-C along with up regulating ATP-binding cassette transporter A1 (ABCA1), apolipoprotein A-1 (ApoA-1) and lecithin-cholesterol acyltransferase (LCAT) mRNA in liver (p < 0.05). These results suggest that ginger extract may have a beneficial effect against obesity-related metabolic disorders with elevating muscle mitochondrial biogenesis and serum HDL-C level. (C) 2016 Elsevier Ltd. All rights reserved. | * |
dc.language | English | * |
dc.publisher | ELSEVIER SCIENCE BV | * |
dc.subject | Ginger | * |
dc.subject | Muscle mitochondrial biogenesis | * |
dc.subject | HDL cholesterol | * |
dc.subject | Metabolic disorder | * |
dc.title | Ginger extract increases muscle mitochondrial biogenesis and serum HDL-cholesterol level in high-fat diet-fed rats | * |
dc.type | Article | * |
dc.relation.volume | 29 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 193 | * |
dc.relation.lastpage | 200 | * |
dc.relation.journaltitle | JOURNAL OF FUNCTIONAL FOODS | * |
dc.identifier.doi | 10.1016/j.jff.2016.12.023 | * |
dc.identifier.wosid | WOS:000393847800023 | * |
dc.identifier.scopusid | 2-s2.0-85007236825 | * |
dc.author.google | Oh, Soojung | * |
dc.author.google | Lee, Mak-Soon | * |
dc.author.google | Jung, Sunyoon | * |
dc.author.google | Kim, Seunghae | * |
dc.author.google | Park, Hyeyoung | * |
dc.author.google | Park, Seonyoung | * |
dc.author.google | Kim, Seog-Young | * |
dc.author.google | Kim, Chong-Tai | * |
dc.author.google | Jo, Young-Hee | * |
dc.author.google | Kim, In-Hwan | * |
dc.author.google | Kim, Yangha | * |
dc.contributor.scopusid | 김양하(8524160300) | * |
dc.date.modifydate | 20240123090847 | * |