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Ginger extract increases muscle mitochondrial biogenesis and serum HDL-cholesterol level in high-fat diet-fed rats

Title
Ginger extract increases muscle mitochondrial biogenesis and serum HDL-cholesterol level in high-fat diet-fed rats
Authors
Oh, SoojungLee, Mak-SoonJung, SunyoonKim, SeunghaePark, HyeyoungPark, SeonyoungKim, Seog-YoungKim, Chong-TaiJo, Young-HeeKim, In-HwanKim, Yangha
Ewha Authors
김양하
SCOPUS Author ID
김양하scopus
Issue Date
2017
Journal Title
JOURNAL OF FUNCTIONAL FOODS
ISSN
1756-4646JCR Link
Citation
vol. 29, pp. 193 - 200
Keywords
GingerMuscle mitochondrial biogenesisHDL cholesterolMetabolic disorder
Publisher
ELSEVIER SCIENCE BV
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Mitochondrial dysfunction and dyslipidemia are associated with obesity-linked metabolic disorders. The aim of this study was to investigate the effects of ginger extract on muscle mitochondrial biogenesis and high-density lipoprotein-cholesterol (HDL-C) metabolism in high-fat diet-fed rats. Supplementation with ginger extract reduced final body weight and epididymal adipose tissue mass without affecting energy intake (p < 0.05). Ginger extract increased mitochondrial size and mitochondrial DNA (mtDNA) content as well as key genes expression related to mitochondrial biogenesis, including peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha), nuclear respiratory factor-1 (NRF-1) and transcription factor A (Tfam) in skeletal muscle (p < 0.05). In addition, ginger extract elevated serum HDL-C along with up regulating ATP-binding cassette transporter A1 (ABCA1), apolipoprotein A-1 (ApoA-1) and lecithin-cholesterol acyltransferase (LCAT) mRNA in liver (p < 0.05). These results suggest that ginger extract may have a beneficial effect against obesity-related metabolic disorders with elevating muscle mitochondrial biogenesis and serum HDL-C level. (C) 2016 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.jff.2016.12.023
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신산업융합대학 > 식품영양학과 > Journal papers
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