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Ginger extract increases muscle mitochondrial biogenesis and serum HDL-cholesterol level in high-fat diet-fed rats
- Ginger extract increases muscle mitochondrial biogenesis and serum HDL-cholesterol level in high-fat diet-fed rats
- Oh, Soojung; Lee, Mak-Soon; Jung, Sunyoon; Kim, Seunghae; Park, Hyeyoung; Park, Seonyoung; Kim, Seog-Young; Kim, Chong-Tai; Jo, Young-Hee; Kim, In-Hwan; Kim, Yangha
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- JOURNAL OF FUNCTIONAL FOODS
- JOURNAL OF FUNCTIONAL FOODS vol. 29, pp. 193 - 200
- Ginger; Muscle mitochondrial biogenesis; HDL cholesterol; Metabolic disorder
- ELSEVIER SCIENCE BV
- SCIE; SCOPUS
- Document Type
- Mitochondrial dysfunction and dyslipidemia are associated with obesity-linked metabolic disorders. The aim of this study was to investigate the effects of ginger extract on muscle mitochondrial biogenesis and high-density lipoprotein-cholesterol (HDL-C) metabolism in high-fat diet-fed rats. Supplementation with ginger extract reduced final body weight and epididymal adipose tissue mass without affecting energy intake (p < 0.05). Ginger extract increased mitochondrial size and mitochondrial DNA (mtDNA) content as well as key genes expression related to mitochondrial biogenesis, including peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha), nuclear respiratory factor-1 (NRF-1) and transcription factor A (Tfam) in skeletal muscle (p < 0.05). In addition, ginger extract elevated serum HDL-C along with up regulating ATP-binding cassette transporter A1 (ABCA1), apolipoprotein A-1 (ApoA-1) and lecithin-cholesterol acyltransferase (LCAT) mRNA in liver (p < 0.05). These results suggest that ginger extract may have a beneficial effect against obesity-related metabolic disorders with elevating muscle mitochondrial biogenesis and serum HDL-C level. (C) 2016 Elsevier Ltd. All rights reserved.
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